The use of individual tracking programs in public health: a bioethics dilemma.

Objective: to understand the bioethical perspectives on mobile tracking device use.

Methods: theoretical study based on action research, carried out with eight graduate students from a public university. A focus group was used, with a thematic content analysis methodology with a codebook structure, approved by the Research Ethics Committee.

Atomoxetine: toxicological aspects of a new treatment for Attention Deficit Hyperactivity Disorder in Brazil.

Atomoxetine is a drug widely used for the treatment of the attention deficit hyperactivity disorder (ADHD) with reduced risk of adverse motor reactions and chemical dependence. However, the pharmacokinetics characteristics as well as the toxicological risk of atomoxetine deserves further investigation to comprehensively analyze the therapeutic and safety aspects of this drug. This study aimed to predict the physicochemical profile and medicinal chemistry characteristics of atomoxetine, alongside its pharmacokinetic properties-namely absorption, distribution, metabolism, and excretion-as well as its toxicology (ADMET) potential through the utilization of web-based in silico tools.

Advancing molecular modeling and reverse vaccinology in broad-spectrum yellow fever virus vaccine development.

Yellow fever outbreaks are prevalent, particularly in endemic regions. Given the lack of an established treatment for this disease, significant attention has been directed toward managing this arbovirus. In response, we developed a multiepitope vaccine designed to elicit an immune response, utilizing advanced immunoinformatic and molecular modeling techniques.

Computational antigenic insights into the novel NADC-34-like Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) isolate YC-2020.

In this computational study, we advanced the understanding of the antigenic properties of the NADC-34-like isolate of the Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), named YC-2020, relevant in veterinary pathology. We utilized sequence comparison analyses of the M and N proteins, comparing them with those of NADC34, identifying substantial amino acid homology that allowed us to highlight conserved epitopes and crucial variants. Through the application of Clustal Omega for multiple sequence alignment and platforms like Vaxijen and AllerTOP for predicting antigenic and allergenic potential, our analyses revealed important insights into the conservation and variation of epitopes essential for the development of effective diagnostic tools and vaccines.

Therapeutic itineraries of quilombola women in northern Minas Gerais, Brazil.

Quilombolas are ethnic-racial groups, of black ancestry, and had their territories consolidated in Brazil in regions with difficult access and far from large centers. The objective of this study is to know the therapeutic itinerary (IT) adopted by quilombola women in traditional communities located in the North of the state of Minas Gerais. This is a qualitative study with the theoretical model using the Arthur Kleinman health care system.

Understanding SARS-CoV-2 spike glycoprotein clusters and their impact on immunity of the population from Rio Grande do Norte, Brazil.

SARS-CoV-2 genome underwent mutations since it started circulating within the human population. The aim of this study was to understand the fluctuation of the spike clusters concomitant to the population immunity either due to natural infection and/or vaccination in a state of Brazil that had both high rate of natural infection and vaccination coverage. A total of 1725 SARS-CoV-2 sequences from the state of Rio Grande do Norte, Brazil, were retrieved from GISAID and subjected to cluster analysis.

[Common Mental Disorders in rural "quilombolas" in the North of Minas Gerais, Brazil].

The scope of this article is to assess the prevalence and factors associated with Common Mental Disorders (CMD) in "quilombolas" (Afro-Brazilian residents of quilombo settlements) in rural communities located in the North of Minas Gerais, Brazil. It is a cross-sectional study of 2019 based on structured interviews and application of a Self-Reporting Questionnaire (SRQ-20). Binary logistic regression was conducted.

[Quilombola men and their work: a mapping of the health of these workers].

Quilombola men perform productive activities that require great physical strength in environments conducive to several risks, accidents, and health problems. This study aimed to map the work processes of quilombola men in three locations in Norte de Minas region in the State of Minas Gerais, Brazil, using the methodological framework of Cartography proposed by Gilles Deleuze & Félix Guattari. Data were produced by the observation of work processes, individual interviews, and records of the effects in a mapping diary.

Genome-wide association studies of COVID-19: Connecting the dots.

Genome-wide association studies (GWASs) are a research approach used to identify genetic variants associated with common diseases, like COVID-19. The lead genetic variants (n = 41) reported by the eleven largest COVID-19 GWASs are mapped to 22 different chromosomal regions. The loci 3q21.

Abdominal obesity and associated factors in quilombola communities in Northern Minas Gerais, Brazil, 2019.

Objective: To analyze the prevalence of abdominal obesity and associated factors in quilombola communities in Northern Minas Gerais, Brazil.

Methods: This was a cross-sectional study conducted in 2019 through structured interviews and waist circumference measurement; Poisson regression was used, separated by gender, to calculate prevalence ratios (PR) of abdominal obesity adjusted by independent variables and 95% confidence interval (95%CI).

Results: 56.

Therapeutic perceptions in antisense RNA-mediated gene regulation for COVID-19.

COVID-19 was first reported in Wuhan, China, in December 2019. It is widely accepted that the world will not return to its prepandemic normality until safe and effective vaccines are available and a global vaccination program has been successfully implemented. Antisense RNAs are single-stranded RNAs that occur naturally or are synthetic and enable hybridizing and protein-blocking translation.

Influence of socioeconomic status, age, body fat, and depressive symptoms on evel of physical activity in adults: a path analysis.

Physical activity is a complex behavior influenced by sociodemographic and clinical factors. A better understanding of the relationships between these factors is essential to better understanding their influence on physical activity. The objective of this study was to examine the association between socioeconomic status, age, body fat, and depressive symptoms and level of physical activity among adults.

Common mental disorders in nursing technicians of a university hospital.

Objective: To verify the prevalence of common mental disorders and associated factors in nursing technicians.

Method: Cross-sectional analytical study conducted at a university hospital. A questionnaire with sociodemographic, educational and work-related variables and the Self Reporting Questionnaire-20 were used to verify the presence of common mental disorders.

Dual immune modulatory effect of vitamin A in human visceral leishmaniasis.

Vitamin A supplementation has shown to prevent mortality by diarrheal and respiratory diseases in several countries. Nevertheless, there are few studies investigating the effect of vitamin A in visceral leishmaniasis (VL), although there are reports of its deficiency in children with symptomatic VL in Brazil and Bangladesh. This study analyzed the effect of vitamin A on a subset of Treg cells and monocytes isolated from symptomatic VL and from healthy children residing in an endemic area for VL in Northeast Brazil.

Leptin receptor polymorphism Gln223Arg (rs1137101) in oral squamous cell carcinoma and potentially malignant oral lesions.

The purpose of this study was to assess the LEPR gene Gln223Arg polymorphism (rs1137101) in oral squamous cell carcinoma (OSCC) and in potentially malignant oral lesions (PMOL) in comparison to normal oral mucosa in a Brazilian population. Smokers (n = 89) were selected from a representative sample of 471 individuals from the general population of Montes Claros, Brazil. Participants were age and gender matched to patients with OSCC (n = 25) and oral epithelial dysplasia (n = 25).

[The impact of risk factors of non-communicable chronic diseases on quality of life].

Quality of life has become an important yardstick of the impact on health. Its evaluation related to diseases and associated risk factors has increased in the population in general. This article seeks to assess the quality of life and the presence of the association with risk factors for non-communicable chronic diseases in the urban population of the city of Montes Claros in the State of Minas Gerais.

Analysis of ECOG performance status in head and neck squamous cell carcinoma patients: association with sociodemographical and clinical factors, and overall survival.

Purpose: In the present study, we analyzed sociodemographical and clinical factors, and the Eastern Cooperative Oncology Group performance status (ECOG-PS) scale in head and neck squamous cell carcinoma (HNSCC) patients. We evaluated the impact of a range of variables on overall survival.

Methods: We investigated a sample of HNSCC patients (n = 671), using sociodemographical and clinical information, and survival data collected from a review of epidemiological, clinical, and treatment reports.

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas.

Visceral leishmaniasis [VL] represents a major public health problem in many areas of the world. This review focuses on the impact of periurbanization on the epidemiology and treatment of VL, using Brazil as an example. VL continues to be mostly a disease of poverty with impact on families.

[Population dynamics and the profile of mortality in the municipality of Montes Claros, Minas Gerais State, Brazil].

This study is an ecological study of time trend. The objective of this study is to assess the population dynamics as the 1980 Census, 1991 and 2000, and the profile of mortality in the period between 1996 and 2005, in Montes Claros, Minas Gerais State. We used the information systems database of Datasus and IBGE.

Prevalence of the use of homeopathy by the population of Montes Claros, Minas Gerais, Brazil.

Context And Objective: Homeopathy is a therapeutic system that uses small doses of substances to stimulate autoregulatory and self-healing processes. The aim of this study was to investigate the prevalence of the use of homeopathy by the population of Montes Claros, Brazil, and the socioeconomic profile of users.

Design And Setting: Probabilistic cross-sectional study with cluster sampling, in the city of Montes Claros, Minas Gerais.

[Models applied to the activities of health education].

This study aimed at determining which educational models have been applied to the activities health education. This is a review of literature on the topic Models of Education and Health Education, using as reference contemporary books of specialists in the field of education and journals on such topics available in major databases. The results showed that the Traditional Model of health education aims to transfer the knowledge and experience of the educator, giving a paramount importance to the content taught, hoping that the students absorb unchanged and faithfully reproduce.