Publications by authors named "Joao F Queiro"
Angew Chem Int Ed Engl
November 2020
Article Synopsis
- Paramagnetic chemical exchange saturation transfer (paraCEST) agents are ideal for imaging tissue pH due to their sensitivity to changes in pH through chemical exchange.
- The new pH-sensitive paraCEST agent developed lacks an inner-sphere water molecule and instead uses a Yb-bound -OH group, providing a distinct CEST peak that correlates with varying pH levels.
- Initial rodent studies indicate that the Gd(1) complex has a prolonged presence in the bloodstream but is eventually cleared slowly through the kidneys.
