Antifungal Activity of -(4-Halobenzyl)amides against spp. and Molecular Modeling Studies.

Fungal infections remain a high-incidence worldwide health problem that is aggravated by limited therapeutic options and the emergence of drug-resistant strains. Cinnamic and benzoic acid amides have previously shown bioactivity against different species belonging to the genus. Here, 20 cinnamic and benzoic acid amides were synthesized and tested for inhibition of ATCC 14243 and ATCC 22019.

Evaluation of the antifungal activity of midazolam against fluconazole-resistant spp. isolates.

The purpose of this study was to evaluate the antifungal activity of midazolam, alone and in association with azoles, against isolates of clinical spp. in planktonic and biofilm form. The antifungal activity was observed using the broth microdilution technique.

Etomidate inhibits the growth of MRSA and exhibits synergism with oxacillin.

The purpose of this study was to evaluate the antimicrobial activity of the anesthetic etomidate against strains of MRSA and biofilms. The antibacterial effect of etomidate was assessed by the broth microdilution method. To investigate the probable action mechanism of the compound flow cytometry techniques were used.

Antifungal activity of β-lapachone against azole-resistant spp. and its aspects upon biofilm formation.

The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of spp. in both planktonic and biofilm form. The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay.

Chemopreventive effect of troxerutin against hydrogen peroxide-induced oxidative stress in human leukocytes through modulation of glutathione-dependent enzymes.

Troxerutin is a natural flavonoid present abundantly in tea, coffee, olives, wheat, and a variety of fruits and vegetables. Due to its diverse pharmacological properties, this flavonoid has aroused interest for treatment of various diseases, and consequently prompted investigation into its toxicological characteristics. The aim of this study was to evaluate the genotoxic and mutagenic effects and chemoprotective activity attributed to troxerutin using human peripheral blood leukocytes (PBLs) through several well-established experimental protocols based upon different parameters.

Antifungal activity of etomidate against growing biofilms of fluconazole-resistant spp. strains, binding to mannoproteins and molecular docking with the ALS3 protein.

This study evaluated the effect of etomidate against biofilms of spp. and analysed through molecular docking the interaction of this drug with ALS3, an important protein for fungal adhesion. Three fluconazole-resistant fungi were used: , and .

Synergistic anticandidal activity of etomidate and azoles against clinical fluconazole-resistant isolates.

The purpose of this study was to evaluate the effect of etomidate alone and in combination with azoles on resistant strains of spp. in both planktonic cells and biofilms. The antifungal activity of etomidate was assessed by the broth microdilution test; flow cytometric procedures to measure fungal viability, mitochondrial transmembrane potential, free radical generation and cell death; as well detection of DNA damage using the comet assay.