Combined Neonatal Alloimmune Neutropenia and Thrombocytopenia in Dizygotic Twins Conceived After Oocyte Donation.

Neonatal alloimmune thrombocytopenia (NAIT) and neonatal alloimmune neutropenia (NAIN) may have severe consequences in the neonatal period. We report two dizygotic twins conceived after donated oocytes, suffering NAIT and NAIN in the context of alloantibodies to human platelet antigens (anti-HPA-5b) and human leukocyte antigens (anti-HLA class I). Genotyping demonstrated paternal homozygosity for HPA-5a, while the neonates were heterozygous for HPA-5b.

IBUPROFEN-INDUCED ASEPTIC MENINGITIS: A CASE REPORT.

Objective: To report a case of a male adolescent with the diagnosis of ibuprofen-induced meningitis. We discuss themain causes of drug-induced aseptic meningitis (DIAM) and highlight the importance of early recognition of DIAM, sothat the offending drug can be withdrawn, and recurrences prevented. Only few DIAM cases have been reported in pediatric age.

[Perinatal transmission of hepatitis C virus - Santo André Hospital, Leiria 2002-2006].

Background: Vertical transmission of hepatitis C virus (HCV) is the main route of infection in children, occurring in few cases (five percent). Current recommendations for HCV screening include first anti-HCV testing at age > 18 months, reducing false positives and false negatives. Positive results must be confirmed by the presence of HCV RNA on two different occasions.