Psychological processes in chronic embitterment: The potential contribution of rumination.

Objective: Chronic embitterment has received considerable attention in terms of its presentation and epidemiology, but there has been relatively little focus on its psychology. The present study aimed to test the hypothesis that embitterment is positively correlated with rumination, and that this effect is influenced by positive beliefs about rumination.

Method: A convenience sample (N = 79) of staff of a health care facility attending its occupational health service completed questionnaires assessing chronic embitterment, work-related rumination (distinguishing affective rumination and problem solving pondering), positive beliefs about rumination, and depression.

Is there information contained within the sentence-writing component of the mini mental state examination? A retrospective study of community dwelling older people.

Objective: To investigate the relationship between features of the MMSE written sentence and cognitive function, depression and disability.

Methods: MMSE sentences from 191 community dwelling individuals without dementia from the Lothian Birth Cohort 1921 (LBC1921) study were: (a) photocopied and (b) typed as written. Sentences were rated for objective criteria: word number and frequency, first person usage, time orientation, and letter case.

Expression of doublecortin (DCX) and doublecortin-like kinase (DCLK) within the developing chick brain.

Doublecortin (DCX) is a microtubule-associated protein widely expressed in the developing mammalian nervous system and important for neuronal migration. DCX is known to belong to a novel protein family defined by sequence homology and the presence of a conserved microtubule-binding domain, but the functions of other members of this family are still undefined. In this study, we describe the cloning of the chick ortholog of doublecortin-like kinase (DCLK), a member of this family, and assess the expression of DCX and DCLK in the layered regions of the developing chick brain.

Multisite phosphorylation of doublecortin by cyclin-dependent kinase 5.

Doublecortin (DCX) is a 40 kDa microtubule-associated protein required for normal neural migration and cortical layering during development. Mutations in the human DCX gene cause a disruption of cortical neuronal migration. Defects in cdk5 (cyclin-dependent kinase 5) also cause defects in neural migration and cortical layering.