TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg and Mg·ATP.

TRPM6 and its homologue TRPM7 are α-kinase-coupled divalent cation-selective channels activated upon reduction of cytosolic levels of Mg and Mg·ATP. TRPM6 is vital for organismal Mg balance. However, mechanistically the cellular role and functional nonredundancy of TRPM6 remain incompletely understood.