Publications by authors named "Joanna Szarkowska"
About 40% of clear cell renal cell carcinoma (ccRCC) cases carry the mutation inactivating BAF180 subunit of the SWI/SNF chromatin remodeling complex (CRC). Here we show that the majority of transcriptomic changes appear at the stage I of ccRCC development. By contrast, the stage II ccRCC exhibits hyperactivation of DNA replication demonstrated by the overexpression of several genes, e.
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- Growing tumors can evade the immune system by exhausting tumor-infiltrating lymphocytes (TILs), which lose their ability to attack cancer cells due to continuous stimulation.
- Breast cancer cells that express PD-L1 contribute to T cell exhaustion by increasing markers like PD-1 and decreasing key genes, leading to reduced T cell numbers and function.
- The study suggests that using epi-drugs, like EZH2 inhibitors, may help restore T cell function and improve cancer treatment outcomes.
Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in () gene. Additionally, in about 40% of ccRCC cases the mutation in () gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found suggesting potential impairment of this complex function in ccRCC. In this study we assessed the extent to which the core SWI/SNF complex subunit - INI1 (hSNF5/SMARCB1) is affected in ccRCC and whether it has any consequences on the development of this type of cancer.
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