Publications by authors named "Joanna Stenzel"
Article Synopsis
- The use of haplo-identical (family) donors for allogeneic stem cell transplantation may help patients who lack matched donors but requires stringent T-cell depletion to prevent severe complications like graft-versus-host disease (GVHD).
- A CD45RA depletion module was tested on the CliniMACS Prodigy device to produce T-cell-depleted products suitable for this purpose, which showed minimal technical issues and a significantly altered T-cell composition.
- Results indicated that the products had a greatly increased CD4:CD8 ratio and reduced allo-reactivity while retaining anti-pathogen responses, suggesting potential benefits for immune reconstitution in transplant patients.
