Publications by authors named "Joanna Silverman"
Background: We summarize a case of transient oculomotor nerve palsy in a pregnant woman with a cavernous sinus meningioma. When pregnant women present with acute ophthalmic signs and symptoms, meningioma should be considered during diagnostic workup given the common proximity of growing meningiomas to visual pathways and ocular motor nerves within the parasellar region.
Case: A 32-year-old woman, gravida 2 para 1, at 37 weeks of gestation, presented with 2 weeks of diplopia, left-sided ptosis, and left periocular headache.
Purpose: To report indications for wear, visual outcomes, and complications of EyePrintPRO (EPP) scleral contact lens (SCL) use.
Methods: A retrospective review identified all patients fitted with this device between December 2013 and March 2018. Baseline demographics, wear indication, and contact lens history were determined.
Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis.
JACC Basic Transl Sci
February 2019
Article Synopsis
- Psoriasis is an inflammatory skin condition that increases the risk of cardiovascular issues and is a useful model for studying inflammation-related heart disease.
- The study highlights the connection between low-density granulocytes (a type of neutrophil) and platelets, specifically how their interaction is linked to the presence of noncalcified coronary plaques measured by coronary CT angiography.
- Since the presence of noncalcified plaques can lead to serious heart attacks, targeting the interaction between low-density granulocytes and platelets could be important for future clinical treatments.
Background: Psoriasis (PSO) is an immune-mediated inflammatory disease associated with metabolic and cardiovascular comorbidities. It is now known that resolution of inflammation is an active process locally controlled by specialized proresolving mediators (SPMs), named resolvins (Rvs), protectins, and maresins.
Objective: It is unknown whether these potent lipid mediators (LMs) are involved in PSO pathophysiology and if the skin and blood have disease-specific SPMs phenotype profiles.
Inflammation is critical to atherogenesis. Psoriasis is a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides a compelling model to understand potential pathways linking these diseases. A murine model capturing the vascular and metabolic diseases in psoriasis would accelerate our understanding and provide a platform to test emerging therapies.
View Article and Find Full Text PDFChronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, a chronic inflammatory skin disease associated with increased susceptibility to atherosclerosis, provides a clinical human model that can be utilized to investigate the links between chronic inflammation and atherosclerosis development. We sought to investigate key biological processes in psoriasis skin and human vascular tissue to identify biological components that may promote atherosclerosis in chronic inflammatory conditions.
View Article and Find Full Text PDFArticle Synopsis
- Inflammation is a key factor in the development of atherosclerosis, and psoriasis, a chronic inflammatory skin disease, is linked to increased vascular inflammation and future cardiovascular issues.
- The study aimed to examine the relationship between the severity of skin disease (measured by PASI score) and vascular inflammation after one year of anti-tumor necrosis factor therapy.
- In a cohort of 115 patients, significant improvements in both skin condition and vascular inflammation were observed, with most patients experiencing a notable decrease in PASI scores and vascular inflammation over the year.
Article Synopsis
- Psoriasis is linked to chronic inflammation and an increased risk of heart problems, and patients with psoriasis often experience depression, raising questions about the impact of depression on vascular health.
- A study matched psoriasis patients with and without reported depression to analyze vascular inflammation and coronary plaque using advanced imaging techniques and statistical methods.
- Findings showed that patients with self-reported depression had higher vascular inflammation and greater coronary plaque burden, suggesting depression could enhance the risk of heart disease in those with psoriasis, despite controlling for traditional risk factors.