Publications by authors named "Joanna S T Asprer"
Neonatal mouse cochlear supporting cells have a limited ability to divide and trans-differentiate into hair cells, but this ability declines rapidly in the two weeks after birth. This decline is concomitant with the morphological and functional maturation of the organ of Corti prior to the onset of hearing. However, despite this association between maturation and loss of regenerative potential, little is known of the molecular changes that underlie these events.
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- * Confirming the quality, identity, and safety of PSCs involves a series of tests that measure specific markers and their functional pluripotency.
- * The article reviews current practices for PSC characterization, discusses challenges in the field, and highlights emerging trends, such as using in silico assays as alternatives to traditional testing methods.
Article Synopsis
- - Induced pluripotent stem cells (iPSCs) are important for disease studies and therapies, but distinguishing fully reprogrammed iPSC colonies from partially reprogrammed ones is a challenge.
- - Current methods using colony appearance and surface markers may not reliably identify fully reprogrammed iPSCs, risking the selection of lower-quality clones for research.
- - The cell adhesion protein CD44 has been identified as a reliable marker that decreases during reprogramming, allowing for improved identification of fully reprogrammed iPSCs when combined with other markers.
The proneural protein neurogenin 2 (NGN2) is a key transcription factor in regulating both neurogenesis and neuronal radial migration in the embryonic cerebral cortex. However, the co-factors that support the action of NGN2 in the cortex remain unclear. Here, we show that the LIM-only protein LMO4 functions as a novel co-factor of NGN2 in the developing cortex.
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