Therapy with high-dose statins reduces soluble P-selectin: The impact on plasma fibrin clot properties.

Objective: Studies on the effect of statins on platelets in patients with coronary artery disease (CAD) yielded inconsistent results. We sought to investigate whether high-dose statin therapy reduces plasma concentrations of soluble P-selectin (sP-selectin), a well-established platelet activation marker and if such changes can affect fibrin clot properties, which are unfavorably altered in CAD patients.

Methods: We studied 130 consecutive patients with advanced CAD who did not achieve the target LDL cholesterol on statins.

Thromboprophylaxis in hospitalized COVID-19 patients: the efficacy and safety of the approved hospital protocol.

Introduction: Prothrombotic coagulopathy in COVID-19 has led to a strong recommendation for thromboprophylaxis in all hospitalized patients, although there are large differences in the dosage regimens among hospitals and their outcomes remain uncertain. Objectives: We aimed to determine the incidence of thrombotic events and bleeding in patients with COVID-19 using the approved local thromboprophylaxis protocol. Patients and methods: We adapted a self-developed pharmacological thromboprophylaxis protocol based on clinical and laboratory risk assessment of thrombosis in 350 consecutive patients (median age, 67 years) with confirmed COVID-19, treated in designated wards at a single center in Kraków, Poland from October 10, 2020, to April 30, 2021.

[Predictive parameters of occurrence of adequate interventions in patients with implanted cardioverter-defibrillators with or without resynchronisation therapy in primary prevention of sudden cardiac death in dilated cardiomyopathy].

Unlabelled: The task of the ICD is to detect ventricular arrhythmias and treatment of its adequate intervention. The task of the CRTD in addition to the above tasks is the treatment of heart failure.

Aim: The aim of the study was to assess the predictive parameters of adequate interventions in patients with an ICD and CRTD.

[The evaluation of the ventricular arrhythmias and interventions of cardiac implantable electronic devices in patients with dilated cardiomyopathy for primary prevention of sudden cardiac death in ambulatory and telemetric follow-up].

Unlabelled: Telemetric follow-up (RM) after cardiac devices implantation is not inferior to classic follow-up and enables earlier clinical complications detection.

Aim: The aim of the study was to evaluation of the ventricular arrhythmias and interventions of ICD/CRTD in ambulatory and telemetric follow-up in patients with dilated cardiomyopathy.

Materials And Methods: Group A (CRT-D+ICD) - retrospective, patients followed-up in outpatient clinic - was consisted with 273 patients (mean age 65±11 years, 230M).

[The assessment of factors influencing occurrence of adequate interventions of cardiac resynchronization therapy with cardioverter-defibrillator implanted in primary prevention of sudden cardiac death in dilative cardiomyopathy and percentage of biventricular pacing].

Unlabelled: The assessment of factors influencing occurrence of adequate interventions of cardiac resynchronization therapy with cardioverter-defibrillator implanted in primary prevention of sudden cardiac death in dilative cardiomyopathy and percentage of biventricular pacing.

Introduction: The function of cardiac resynchronization therapy with cardioverter-defibrillator (CRT-D) is to treat heart failure (HF) and to treat ventricular arrhythmia, if it occurs, with adequate intervention.

Aim: The aim of the study was to find predictors of adequate interventions and in how many patients biventricular pacing percentage decreases during the follow-up.

Patients with diabetes mellitus have better lipid profile results compared to the controls - a retrospective study on a group of patients hospitalized due to pulmonary embolism.

Background: Pulmonary embolism is a clinical manifestation of venous thromboembolism (VTE), also comprising deep vein thrombosis. It is considered to be a consequence of environmental and genetic factors. The number of predisposing risk factors is high.

[Safety and efficacy of classic ambulatory implantable cardioverter-defibrillator and resynchronisation systems follow-up compared to telemetric follow-up].

Unlabelled: Telemetric follow-up (RM) after cardiac devices implantation is not only not inferior to classic follow-up, but also enables earlier clinical complications detection and stricter patient monitoring.

The Aim: of the study was to confirm safety and efficacy of RM in patients with implantable cardioverter-defibrillator (ICD) or cardioverterdefibrillator with resynchronisation therapy (CRT-D), compared to traditional follow-up in outpatient clinic.

Materials And Methods: Group A (CRT-D+ICD) (retrospective, patients followed-up in outpatient clinic) was consisted with 273 patients (mean age 65±11 years, 230M).

[Ventricular arrhythmia and device intervention analysis in patients with implanted cardioverter-defibrillator with/without resynchronisation therapy in dilative cardiomyopathy in primary prevention of sudden cardiac death in telemetric follow-up].

Introduction: Remote monitoring of ICD/CRTD is safe, during which evaluates the type of arrhythmia, intervention.

Aim: The aim of the study was the assessment of ventricular arrhythmia and ICD/CRTD intervention.

Material And Methods: The study included 177 patients (mean age 61,1±13; 23-88 y; Men 141) with an ICD/CRTD implanted.

[Factors predisposing to the reprogramming of implantable cardioverter-defibrillators and the causes of changes in pharmacotherapy in patients with dilated cardiomyopathy for primary prevention of sudden cardiac death].

Unlabelled: Ambulatory care of patients with implantable cardioverter-defibrillator (ICD) involves regular follow-up visit, where a decision on reprogramming of the device and modification of pharmacotherapy is made.

Aim: The aim of the study was the assessment of frequency and reasons of reprogramming and pharmacotherapy changes in patients with dilated cardiomyopathy with an ICD implanted due to primary prevention of sudden cardiac death (SCD).

Materials And Methods: The study included 143 consecutive patients with an ICD implanted in 2010-2011.

[Analysis of RF ablation treatment on quality of life in patients with cardiac arrhythmias].

Background: RF ablation is an acknowledged method of treatment for many arrhythmias. During the ablation procedure the cause of the arrhythmia is eliminated, which results in resolution of cardiac arrhythmia and related clinical manifestations and therefore removes restrictions in the functioning of the patient, which were associated with the presence of arrhythmias.

Aim Of The Study: Was to assess quality of life in patients undergoing RF ablation due to atrioventricular nodal reciprocating tachycardia--VNRT, atrioventricular reciprocating tachycardia -AVRT and ventricular ectopic beats --EB's using the SF-36 questionnaire, DASI and Manolis.

[Electrocardiologic opportunities for the treatment of recurrent ventricular tachycardia on the example of a patient with arrhythmogenic right ventricular dysplasia].

Arrhythmogenic right ventricular dysplasia is a genetic disease, in which pathologic fibrofatty tissue occurs mainly in the right ventricle of the heart. Changes in heart muscle predispose to arrhythmias such as ventricular tachycardia or ventricular fibrillation, so these patients are candidates for implantation of implantable cardioverter-defibrillator. Furthermore, depending on the indication, RF-ablation is performed, which, due to changes in morphology of the heart muscle, are often difficult and of uncertain efficacy.

[Analysis of P wave duration and dispersion in paroxysmal atrial fibrillation].

Unlabelled: Some findings in standard electrocardiogram (ECG) may be associated with paroxysmal atrial fibrillation (AF). The aim of the study was to evaluate P wave duration and P wave dispersion (Pdysp) derived from 12-lead standard surface ECG in sinus rhythm in patients with history of AF in comparison to control subjects without AF and with premature ventricular ectopic beats (PVEB).

Material And Methods: The study group consisted of 20 patients (pts), 9M.

[Quality of life in patients after anti-arrhythmic devices implantation].

The Aim Of Study: To assess changes in quality of life in patients with advanced heart failure before ICD or CRTD implantation and after 6 months follow-up period.

Material And Methods: The quality of life study was performed in group consisting of 98 patients (69 male, mean age 70.4 +/- 8.

[Electrocardiogram in the cardiovascular rare diseases].

Electrocardiography is a method which can not be replaced by any other examination in arrhythmias. It also plays a crucial role in the diagnosis of arrhythmic rare diseases by providing not only diagnostic data, but also paving the way for treatment. This article presents some characteristic examples of ECG in arrhythmic rare diseases (i.

[Effectiveness of RF ablation of ventricular ectopic beats from the right and (or) left ventricle].

Unlabelled: There are few studies on the immediate and long term efficacy of ablation of ventricular ectopic beat (VEB) using different mapping systems arrhythmia. The aim of the study was to evaluate the efficacy of intraoperative, immediate and late outcome of RF ablation ventricular arrhythmias and a comparison of methods for identification and ablation of arrhythmia substrate.

Material And Methods: In 88 patients, average age 50,8+/-17,8 years old (16 to 90) with performed RF ablation of VEB from the left ventricular and (or) right ventricular.

[The comparison of 4th, 5th and 6th year medical students knowledge of rules and practical skills in the interpretation of electrocardiograms at Jagiellonian University].

Introduction: The electrocardiogram (ECG) examination is one of the most frequent administered diagnostic tests. It is commonly ordered by General Practitioners, and it has became a routinely administered examination during admission to the hospital. During their studies, medical students has numerous opportunities to review and interpret the results of these tests.

[Influence of increased mean heart rate at rest on mortality and ventricular tachycardia resulting in adequate intervention in patients after implantable cardioverter-defibrillator implantation].

Introduction: Increased heart rate at rest (HR) is a risk factor of sudden cardiac death (SCD) and cardiovascular mortality.

Aim: Retrospective assessment of increased HR influence on mortality and ventricular tachycardia followed by adequate ICD intervention.

Material And Methods: 350 patients (52 female, 298 male), mean age 65.