Rotational Thromboelastometry (ROTEM) in Relation to Inflammatory Biomarkers and Clinical Outcome in COVID-19 Patients.

The pathogenesis of hypercoagulability in COVID-19 patients is complex and not fully understood. Rotational thromboelastometry (ROTEM) is a viscoelastic method that allows the definition of a patient's hemostatic profile. This study aimed to assess the relationship between ROTEM parameters, the profile of inflammatory cytokines, and clinical outcomes in COVID-19 patients.

Flow-cytometry-based evaluation of peripheral blood lymphocytes in prognostication of newly diagnosed DLBCL patients.

Aims: We aimed to analyse whether quantitative assessment of peripheral blood lymphocyte CD19(+)CD20(+)CD22(+)CD79a(+) B cells, CD3(+)CD4(+)CD5(+)CD8(+) T cells and CD4(+)CD25(+++)Foxp3high Treg can improve prognostication in DLBCL patients.

Methods: The absolute count of lymphocytes, B-cells, T-cells and Treg-cells as well as the percentage of apoptotic cells were assessed by means of flow cytometry in all studied subjects.

Results: Significantly lower level of ALC and the percentage of apoptotic cells have been observed exclusively in DLBCL patients with HR.

Utility of laboratory tests in B-CLL patients in different clinical stages.

The study objective was to analyse the utility of laboratory tests performed in 30 patients with B-cell chronic lymphocytic leukaemia (B-CLL) at different clinical stages. Laboratory tests included automated and microscopic assessment of peripheral blood and bone marrow counts as well as evaluation of leukaemic cells. Apart from the diagnostic and prognostic value of laboratory abnormalities such as clonal lymphocytosis with CD5+CD19+CD23+ phenotype, reduced erythrocyte parameters, thrombocytopenia or bone marrow infiltration by the neoplastic clone as well as low percentage of Gumprecht's shadows, low apoptotic activity of peripheral blood lymphocytes, and increased percentage of CD38- and ZAP-70 ± cells markedly correlate with the stage of disease progression.

[Parameters of platelets activation and myeloperoxidase concentration as markers of coronary disease].

Ischemic heart disease is mainly caused by atherosclerosis and its complications. Platelets have important role in initiation of atherosclerotic lesions. Increase platelet activation and aggregation within coronary circulation initiate thrombus formation at a ruptured or eroded plaque.