Publications by authors named "Joanna McLorinan"
Background: Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5-DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 is an RNA sensor and a key pattern recognition receptor for the SARS-CoV-2 virus.
Methods: This is a retrospective observational study of a surge in MDA5 autoimmunity, as determined using a 15 muscle-specific autoantibodies (MSAs) panel, between Janurary 2018 and December 2022 in Yorkshire, UK.
Background: Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5 -DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 senses single-stranded RNA and is a key pattern recognition receptor for the SARS-CoV-2 virus.
Methods: This is a retrospective observational study of a surge in MDA5 autoimmunity, as determined using a 15 muscle-specific autoantibodies (MSAs) panel, between Janurary 2018-December 2022 in Yorkshire, UK.
Article Synopsis
- Some vaccines, including those for SARS-CoV-2, can trigger or worsen immune-mediated diseases (IMDs) due to their unique mechanisms of action involving TLR agonism.
- A study evaluated 27 cases of new-onset or flare-up of IMDs within 28 days of receiving SARS-CoV-2 vaccines across five major medical centers in Israel, the UK, and the USA, with most cases linked to the BNT-162b2 vaccine.
- The majority of cases were mild to moderate in severity, with notable recovery in over 80% of patients, often with corticosteroid treatment, and a large number of IMD occurrences could not be directly linked to the specific vaccine administered.
Aims: The National Institute for Health and Care Excellence advocated the development of specialist skin cancer multidisciplinary teams (SSMDTs) for the management of higher risk invasive skin cancers in the UK. The interobserver variability in the histopathological assessment of primary cutaneous malignant melanoma (PCMM) is well recognised.
Methods: We evaluated the discordance rates in the assessment of the histopathological criteria of PCMM based on the eighth American Joint Committee on Cancer (AJCC) melanoma staging system and subsequent change in prognosis and management following pathology review by an SSMDT.