The Effect of Corticotomy-Assisted Orthodontic Therapy (CAOT) or Periodontally Accelerated Osteogenic Orthodontics (PAOO) on Bone Remodeling and the Health of Periodontium: A Systematic Review of Systematic Reviews.

Orthodontic treatment involves moving teeth within the alveolar ridge. Bone remodeling is associated with the activity of osteoblasts and osteoclasts. Procedures such as corticotomy-assisted orthodontic therapy (CAOT) or periodontally accelerated osteogenic orthodontics (PAOO) are intended to reduce bone density and negative stress on the grip side and therefore limit bone resorption during orthodontic movement or add bone substitute material so that the tooth does not cross the vestibular plate.

Evaluating the accuracy of one-piece and three-piece 3D-printed indirect bonding transfer trays: An in vitro study.

Background: Recent developments in computer-aided design/computer-aided manufacturing (CAD/CAM) and 3D printing have enabled the fabrication of digital indirect bonding (IDB) transfer trays. These modern products require thorough investigation.

Objectives: The aim of the study was to determine the accuracy of one-piece and three-piece IDB transfer trays in vitro.

Correlation of sex hormone levels with orthodontic tooth movement in the maxilla: a prospective cohort study.

Background: Sex hormones secreted during the menstrual cycle and the application of orthodontic forces to teeth can affect the metabolism of periodontal ligaments. This study aimed to determine whether there are any differences in orthodontic tooth displacement during the menstrual cycle and when using hormonal contraceptives and whether the amount of female sex hormones influences the efficiency of tooth displacement.

Methods: A total of 120 women aged between 20 and 30 years with Angle Class II requiring transpalatal arch (TPA) to derotate teeth 16 and 26 were included in this study.

The Hydrostatic Pressure Distribution in the Periodontal Ligament and the Risk of Root Resorption-A Finite Element Method (FEM) Study on the Nonlinear Innovative Model.

Excessive orthodontic force can induce inflammatory tooth root resorption due to sustained high stresses within the periodontal ligament (PDL). This study aimed to analyze the PDL pressures during upper incisor retraction using the en masse method with TISAD. The finite element method (FEM) ensured consistent conditions across cases.

Bone Remodeling of Maxilla after Retraction of Incisors during Orthodontic Treatment with Extraction of Premolars Based on CBCT Study: A Systematic Review.

Incisor retraction is often a crucial phase in ongoing orthodontic treatment, with significant implications for alveolar remodeling mechanisms. There are two prevailing theories which seek to explain this. According to the first, teeth move with the bone, while according to the second, teeth move within the bone.

Comparison of Diagnostic Validity of Cephalometric Analyses of the ANB Angle and Tau Angle for Assessment of the Sagittal Relationship of Jaw and Mandible.

Background: Cephalometric analysis is an essential tool used in orthodontic diagnosis and treatment planning. The aim of this study was to evaluate the reliability and repeatability of new cephalometric points introduced in Tau angle analysis, in contrast to the gold standard, which is the analysis of the ANB angle. For this purpose, an attempt was made to assess the repeatability and reliability of the introduction of anthropometric points by evaluating both inter- and intraobserver parameters, as well as the agreement among the orthodontists participating in the study.

The Assessment of the Rank of Torque Control during Incisor Retraction and Its Impact on the Resorption of Maxillary Central Incisor Roots According to Incisive Canal Anatomy-Systematic Review.

Background: Root resorption is one of the complications of orthodontic treatment, and has a varied and unclear aetiology.

Objective: To evaluate the relationship between upper incisor resorption and contact with the incisive canal and the risk of resorption during orthodontic treatment associated with upper incisor retraction and torque control.

Search Methods: According to PRISMA guidelines, the main research question was defined in PICO.

The Impact of Progesterone and Estrogen on the Tooth Mobility.

: Progesterone and estrogen modify the bone metabolism directly related to the periodontium, this study aimed at answering the question whether fluctuations in the levels of these hormones or the use of their synthetic equivalents in modern contraceptives have a significant impact on the natural tooth mobility (TM) in its alveolus. : Sixty healthy women who had never been pregnant and when interviewed reported either (1) having regular menstruations every 28-30 days or (2) taking oral two-phase two-ingredient hormonal contraceptives formed, respectively, groups M and S in the study. TM evaluated as the Periotest value (PTV) was checked in the menstruation, ovulation, and luteal phases of the menstrual cycle (group M) and on the days corresponding to the moment of the menstrual cycle in group S.

Are Currently Selected Laboratory Animals Useful in the Research of How Female Hormones Influence Orthodontic Biomechanics?

Animal testing was and remains the only method of introducing a certain treatment and medical procedure on humans. On the other hand, animals have their rights resulting from applicable legal acts, including Directive 2010/63/EU and, indirectly, the World Medical Association International Code of Medical Ethics (Helsinki Declaration, 1975, amended 2000). Thus, the question arises whether the credibility of the results of hormonal and orthodontic tests obtained so far and their usefulness for the human population is scientifically justified and worth sacrificing laboratory animals for.

Evidence-based selection of orthodontic miniscrews, increasing their success rate in the mandibular buccal shelf. A randomized, prospective clinical trial.

Background: Skeletal anchorage has made it possible to perform complex orthodontic tooth movements that are difficult or even impossible to achieve with conventional orthodontic treatment. Mandibular buccal shelf miniscrews, used for distalization, play a particularly important role in treatment of Class III malocclusion. Unfortunately, stability of the miniscrews placed in the mandible is still considered at higher risk of failure compared to other intraoral locations.

Influence of Lip Projection and Chin Position on Facial Profile Preferences Among Various Layers of Polish Population. Part 1.

Purpose: This study aims to evaluate how the extent of altering lip projection in women and chin position in men influences the 22-year-old Caucasian's facial profile attractiveness, in relation to respondents' sex, age and place of residence.

Materials And Methods: One female and one male orthognathic (SNA angle = 79-85°, Z angle = 75-78°) face profiles, with lips correctly positioned in relation to the E-line were photographed and digitally modified. This processing resulted in 30 photographs varying as for 1.

Orthodontic Treatment of Dogs during the Developmental Stage: Repositioning of Mandibular Canine Teeth with Intercurrent Mandibular Distoclusion.

Linguoverted mandibular canines are relatively rare among craniofacial abnormalities, and they are an isolated anomaly. They are most often caused by non-genetic factors such as persistent deciduous canine teeth or trauma coinciding with the eruption of permanent teeth. Another factor may be mandible narrowing or underdevelopment in the transverse dimension and vestibular inclination of the maxillary canine teeth.

Orthodontic Compliance Assessment: A Systematic Review.

Objectives: The aim of this review was to determine whether the type of removable appliance, as well as the age and sex of the patient, may affect the extension or reduction of wear time by assessing the correlation between the mean actual and orthodontist-recommended wear times.

Methods: Randomised case control trials, cohort studies, case series, observational studies, reviews, and retrospective analyses were identified. The quality of the studies was assessed using the Cochrane Collaboration Tool and modified Newcastle-Ottawa Scale.

New Sagittal and Vertical Cephalometric Analysis Methods: A Systematic Review.

Cephalometric analysis is an essential tool used in orthodontic diagnosis and treatment planning. The main objectives of correct cephalometric analysis include resolving anteroposterior and vertical maxillary and mandibular base discrepancies. For a diagnostic tool to be of value, it should be precise, reliable and reproducible.

Changes in the Mandible Following Rapid Maxillary Expansion in Children with Class II Malocclusion: A Systematic Review.

Objective: The aim of this systematic review was to determine whether rapid maxillary expansion (RME) allows favorable changes in the mandible during the treatment of class II malocclusion before the growth spurt.

Methods: A search of Pubmed/Medline, the Science Direct, and the Google Scholar database was performed. The keywords used were: orthodontics, rapid maxillary expansion, class II, and growing patients.

Methods of Anterior Torque Control during Retraction: A Systematic Review.

Background: There are various methods of controlling the inclination of the incisors during retraction, but there is no evidence as to the advantages of some methods over others. The purpose of this systematic review and meta-analysis was to determine the effectiveness of the methods used to control torque during anterior teeth retraction.

Methods: In accordance with the PRISMA guidelines, the main research question was defined in the PICO format [P: patients with complete permanent dentition; I: the maxillary incisor torque after (I) and before I retraction with straight-wire appliance and different modes of torque control; O: statistically significant differences in torque values of the upper incisors after orthodontic treatment].

The Use of Microsensors to Assess the Daily Wear Time of Removable Orthodontic Appliances: A Prospective Cohort Study.

Orthodontic treatment with removable appliances is still common in children and adolescents. However, their effectiveness depends primarily on the patients' compliance. Currently, it is possible to check the daily wear time (DWT) of the removable appliances using special microsensors.

Assessment of the reliability of measurements taken on digital orthodontic models obtained from scans of plaster models in laboratory scanners. A systematic review and meta-analysis.

Background: In recent years, digital models have become increasingly popular among orthodontists, both for clinical and scientific purposes. It is, therefore, crucial to appropriately investigate their reliability. To this date, however, there has been no scientific, statistical investigation of their reliability as compared to the traditional gold standard-plaster models in the form of a meta-analysis.

Characterization of Biological Properties of Dental Pulp Stem Cells Grown on an Electrospun Poly(l-lactide--caprolactone) Scaffold.

Poly(l-lactide--caprolactone) (PLCL) electrospun scaffolds with seeded stem cells have drawn great interest in tissue engineering. This study investigated the biological behavior of human dental pulp stem cells (hDPSCs) grown on a hydrolytically-modified PLCL nanofiber scaffold. The hDPSCs were seeded on PLCL, and their biological features such as viability, proliferation, adhesion, population doubling time, the immunophenotype of hDPSCs and osteogenic differentiation capacity were evaluated on scaffolds.

Clinical and economic impact of a one-year treatment with omalizumab in patients with severe allergic asthma within a drug programme in Poland.

Background: Allergic asthma is the most prevalent phenotype of severe asthma where treatment with omalizumab (OMB) has been proven to be particularly beneficial. In Poland, OMB therapy is available and reimbursed within a drug programme where strict inclusion and exclusion criteria are defined. The objective of this study was to present a descriptive analysis regarding the trends in outcomes (clinical, quality of life, costs) among a cohort of patients who satisfy inclusion criteria for the initiation of OMB treatment and who successfully responded to OMB according to a set of objective criteria.

Systematic review and meta-analysis of randomized clinical trials comparing efficacy and safety outcomes of insulin glargine with NPH insulin, premixed insulin preparations or with insulin detemir in type 2 diabetes mellitus.

Aims: A variety of basal insulin preparations are used to treat patients with type 2 diabetes mellitus (T2DM). We aimed to summarize scientific evidence on relative efficacy and safety of insulin glargine (IGlar) and other insulins in T2DM.

Methods: A systematic review was carried out in major medical databases up to December 2012.

Leflunomide in monotherapy of rheumatoid arthritis: meta-analysis of randomized trials.

Introduction: Rheumatoid arthritis (RA) is a chronic systemic disease of the connective tissue that leads to progressive joint destruction, disability, withdrawal from occupational activity, and premature death.

Objectives: The aim of the paper was to evaluate the efficacy and safety of leflunomide compared with placebo, methotrexate, and sulfasalazine in monotherapy of RA.

Patients And Methods: A systematic search of databases (MEDLINE, EMBASE, Cochrane CENTRAL) was performed.

What do international pharmacoeconomic guidelines say about economic data transferability?

Objectives: The objectives of this article were to assess the positions of the various national pharmacoeconomic guidelines on the transferability (or lack of transferability) of clinical and economic data and to review the methods suggested in the guidelines for addressing issues of transferability.

Methods: A review of existing national pharmacoeconomic guidelines was conducted to assess recommendations on the transferability of clinical and economic data, whether there are important differences between countries, and whether common methodologies have been suggested to address key transferability issues. Pharmacoeconomic guidelines were initially identified through the ISPOR Web site.

[Educational standards of the Polish Pharmacoeconomic Society].

The objective of creating Educational Standards of the Polish Pharmacoeconomic Society (Polish Chapter of the International Society for Pharmacoeconomics and Outcomes Research) was to define and establish a scope of knowledge and skills needed for people conducting and interpreting pharmacoeconomic analyses as well as health technology assessments. A Working Group of the Society identified target groups and divided the requirements into 3 groups: basic, intermediate and advanced. The document reflects conditions of the Polish healthcare and educational systems and is harmonized with international regulations in the field of pharmacoeconomics, outcomes research and health technology assessment.

Transferability of economic evaluations across jurisdictions: ISPOR Good Research Practices Task Force report.

ABSTRACT A growing number of jurisdictions now request economic data in support of their decision-making procedures for the pricing and/or reimbursement of health technologies. Because more jurisdictions request economic data, the burden on study sponsors and researchers increases. There are many reasons why the cost-effectiveness of health technologies might vary from place to place.