Publications by authors named "Joanna Krupp"
Article Synopsis
- The opioid overdose epidemic is worsening, and access to medications for opioid use disorder in primary care is vital, but the effects of recent policy changes on buprenorphine prescribing are still uncertain.
- A survey conducted among primary care providers showed that while a majority encounter patients with opioid use disorder, only a small fraction have the necessary waiver to prescribe buprenorphine, and many perceive significant barriers to prescribing.
- While the policy change had little impact on the decision to obtain a waiver for many providers, it did motivate some interested providers to pursue it; overall, structural challenges, such as lack of experience and resources, hindered broader adoption of buprenorphine prescribing.
Objectives: There is emerging interest and data supporting the effectiveness of community health workers (CHWs) in non-communicable diseases (NCDs) in low/middle-income countries (LMICs). This study aimed to determine whether a CHW-led intervention targeting diabetes and hypertension could improve markers of clinical disease control in rural Mexico.
Design And Setting: A prospective observational stepped-wedge study was conducted across seven communities in rural Chiapas, Mexico from March 2014 to April 2018.
To successfully colonize host tissues, bacteria must respond to and detoxify many different host-derived antimicrobial compounds, such as nitric oxide (NO). NO has direct antimicrobial activity through attack on iron-sulfur (Fe-S) cluster-containing proteins. NO detoxification plays an important role in promoting bacterial survival, but it remains unclear if repair of Fe-S clusters is also important for bacterial survival within host tissues.
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- The dietary specialist fruit fly has adapted to thrive on the toxic fruit of its host plant, which contains high levels of octanoic acid (OA).
- Previous research using RNA interference (RNAi) indicated that certain genes are crucial for resistance to OA, revealing that multiple regions of the genome influence this trait.
- In this study, RNA-sequencing was used to identify 104 differentially expressed genes in response to OA exposure, highlighting new candidate genes and their roles in cuticle development and immune responses that may contribute to OA resistance.