Publications by authors named "Joanna Kaminska"

Objectives: This study quantified blood bicarbonate (HCO) kinetics and gastrointestinal upset to determine the gender-related ergogenic potential of sodium bicarbonate (0.15-, 0.25- and 0.

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  • The research investigates the silage quality of a specific crop harvested at different times (58, 68, and 90 days after sowing) for use as animal feed in northern Europe.
  • Results showed that harvesting at 58 days yielded poor silage, while 68 days provided decent quality but still had low dry matter, necessitating extra wilting.
  • The best silage quality was achieved at 90 days after sowing, demonstrating that this crop can produce acceptable silage even in cooler conditions when wilting is limited.
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  • IGHMBP2 pathogenic variants are linked to two severe neurodegenerative diseases: the fatal spinal muscular atrophy with respiratory distress type 1 (SMARD1) and the milder Charcot-Marie-Tooth type 2S (CMT2S) neuropathy.
  • Despite over two decades of research, the specific mechanisms by which IGHMBP2 mutations cause these diseases remain unclear, although its role as an RNA/DNA helicase has been identified.
  • The review discusses the clinical characteristics of IGHMBP2-related diseases, available model systems for research, the protein's structure, and potential causes of neurodegeneration associated with these conditions.
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Background: The measurement of handgrip force responses is important in many aspects, for example: to complement neurological assessments, to investigate the contribution of muscle mass in predicting functional outcomes, in setting realistic treatment goals, evaluating rehabilitation strategies. Normative data about handgrip force can assist the therapist in interpreting a patient's results compared with healthy individuals of the same age and gender and can serve as key decision criteria. In this context, establishing normative values of handgrip strength is crucial.

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Research on the markers of autoimmune response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of plasma 20S constitutive proteasome, 20S immunoproteasome, and cathepsin S concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface plasmon resonance imaging (SPRI) biosensors were used for the evaluation of protein concentrations.

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The significant role of increased activation of 20S proteasomes in the development of abdominal aortic aneurysms has been well-established in a mouse model. The available literature lacks similar studies concerning brain aneurysms. The aim of the study was to verify the hypothesis that patients with unruptured intracranial aneurysms (UIA) have increased 20S proteasome ChT-L activity compared to the control group of individuals without vascular lesions in the brain.

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Given the low protein coverage by legumes in Poland, alternatives (with high protein content and high nutritional value) are being sought (with high protein content and high nutritional value of protein) that could replace these plants. Cereal cultivation dominates in Poland; hence, the search for high-value plants will also consider this group of plants. The aim of the study was to compare the nutritional value of proteins from two wheat cultivars.

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Exercise-induced metabolic processes induce muscle acidification which contributes to a reduction in the ability to perform repeated efforts. Alkalizing agents such as sodium bicarbonate (NaHCO) prevent large blood pH changes, however, there is no evidence on whether regulation of acid-base balance may also support whole body homeostasis monitored through heamatological and biochemical blood markers in a dose-dependent manner. Thirty Cross-Fit-trained participants were studied in a randomized, multi cross-over, placebo (PLA)-controlled double-blind manner in which they performed a control session (CTRL, without supplementation), three NaHCO visits (three different doses) and PLA (sodium chloride in an equimolar amount of sodium as NaHCO).

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The literature data regarding the risk of colorectal cancer (CRC) in the context of hormone therapy (HT), including both estrogen-progestogen combinations and estrogen alone, are inconclusive. The precise relationship underlying the action of progesterone (P4) and progesterone receptors in CRC has yet to be determined. We characterized the expression profiles of both nuclear and membrane progesterone receptors and their potential cofactors in CRC tissues.

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Background: Musculoskeletal disorders (MSDs), especially in the lumbar spine, are a leading concern in occupational health. Work activities associated with excessive exposure are a source of risk for MSDs. The optimal design of workplaces requires changes in both sitting and standing postures.

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BACKGROUND Thromboembolic episodes, which are largely mediated by blood platelets, are prevalent chronic complications of diabetes. The mean platelet volume (MPV) serves as a marker for in vivo platelet activation. This study aimed to assess the factors influencing MPV in 106 patients with type 2 diabetes, compared with 59 non-diabetic individuals at a single center in Poland.

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Struvite is regarded as a promising phosphorus fertilizer alternative to mineral fertilizers; however before fertilizing, soil tests should be undertaken to determine fertilizer recommendations. In May 2022, soil was sampled from a pot experiment with the application of phosphorus set up at the Wroclaw University and Environmental and Life Sciences. Chemical analysis of the soil included total and available phosphorus, potassium, magnesium determined by the Egner-Riehm, Mehlich 3 and Yanai methods.

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Bicuspid aortic valve (BAV) affects 0.5-2% of the general population and constitutes the major cause of severe aortic valve stenosis (AVS) in individuals ≤70 years. The aim of the present study was to evaluate the parameters that may provide information about the risk of AVS developing in BAV patients, with particular emphasis on lipoprotein(a) (Lp(a)), which is a well-recognized risk factor for stenosis in the general population.

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Mutations in the four human genes , encoding vacuolar protein sorting 13 (VPS13A-D) proteins, result in developmental or neurodegenerative diseases. Understanding the functioning of VPS13 proteins in physiology and pathology is a hot topic of research. Especially interesting is how VPS13 proteins are localized to specific membrane contact sites and function in lipid transport.

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The DNA double-strand breaks are particularly deleterious, especially when an error-free repair pathway is unavailable, enforcing the error-prone recombination pathways to repair the lesion. Cells can resume the cell cycle but at the expense of decreased viability due to genome rearrangements. One of the major players involved in recombinational repair of DNA damage is Rad51 recombinase, a protein responsible for presynaptic complex formation.

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Aim: The aim of our retrospective study was search for new prognostic parameters, which can help quickly and cheaply identify patients with risk for severe course of SARS-CoV-2 infection.

Materials And Methods: The following peripheral blood combination biomarkers were calculated: NLR (neutrophil/lymphocytes ratio), LMR (lymphocyte/monocyte ratio), PLR (platelet/lymphocyte ratio), dNLR (neutrophils/(white blood cells - neutrophils)), NLPR (neutrophil/(lymphocyte × platelet ratio)) in 374 patients who were admitted to the Temporary Hospital no 2 of Clinical Hospital in Bialystok (Poland) with COVID-19. The patients were divided into four groups depending on the severity of the course of COVID-19 using MEWS classification.

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Cerebrospinal fluid plays a crucial role in protecting the central nervous system (CNS) by providing mechanical support, acting as a shock absorber, and transporting nutrients and waste products. It is produced in the ventricles of the brain and circulates through the brain and spinal cord in a continuous flow. In the current review, we presented basic concepts related to cerebrospinal fluid history, cerebrospinal fluid production, circulation, and its main components, the role of the blood-brain barrier and the blood-cerebrospinal fluid barrier in the maintenance of cerebrospinal fluid homeostasis, and the utility of Albumin Quotient (Q) evaluation in the diagnosis of CNS diseases.

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In this study we conducted air pollution monitoring using three different methods: active monitoring with the use of high volume aerosol sampler and biomonitoring with the use of lichens and spider webs. All of these monitoring tools were exposed to air pollution in Legnica city, a region of Cu-smelting in the SW Poland, which is well known for exceeding the environmental guidelines. Quantitative analysis was carried out for the particles collected by the three selected methods and concentrations of seven selected elements (Zn, Pb, Cu, Cd, Ni, As, Fe) were obtained.

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This double-blind placebo-controlled cross-over study utilized comprehensive monitoring of blood bicarbonate (HCO) kinetics and evaluation of gastrointestinal (GI) upset to determine their impact on an ergogenic potential of sodium bicarbonate (SB) co-ingested with carbohydrate (CHO). Nineteen CrossFit athletes performed 6 bouts of 15 s Wingate Anaerobic Test (WAnT) 90 min post-ingestion of 0.4 g·kg body mass (BM) of SB (SB + CHO treatment) or PLA (PLA + CHO treatment) with 15 g CHO.

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Studying the air quality and exposure of the inhabitants of urban agglomerations to pollution is the basis for the creation and development of more sustainable cities. Although research on black carbon (BC) has not yet reached the official acceptable levels and guidelines, the World Health Organization clearly indicates the need to measure and control the level of this pollutant. In Poland, monitoring of the level of BC concentration is not included in the air quality monitoring network.

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Research on the markers of immunoregulatory response in multiple sclerosis (MS) is still of great importance. The aim of our study was the evaluation of leptin, fibronectin, and UCHL1 concentrations as potential biomarkers of a relapsing-remitting type of MS (RRMS). Surface Plasmon Resonance Imaging (SPRI) biosensors were used for the evaluation of proteins concentrations in 100 RRMS patients and 46 healthy volunteers.

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The polluted air breathed every day by those living in large conurbations poses a significant risk to their health. Through effective modelling (prediction) of concentrations of pollutants and identification of the factors influencing them, it should be possible to obtain advance information on dangers and to plan and implement measures to reduce them. This work describes two different modelling approaches: based on the NO concentration of the previous hour (C&RT models); and based on meteorological factors, traffic flow, and past (up to two previous hours) NO and NO concentrations (CA models).

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Background: The purpose of this study was to assess the benefit of the contralateral esophageal sparing technique (CEST) in definitive radiotherapy of non-small cell lung cancer (NSCLC).

Materials And Methods: We retrospectively reviewed radiation plans for 13 patients who underwent definitive chemoradiation for locally advanced NSCLC. Alternative plans were prepared with the use of CEST, with an additional margin of 5 mm from planning treatment volume (PTV).

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One of the goals of human genetics is to discover the variants that contribute to human diseases [...

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