APOE gene epsilon polymorphism does not determine predisposition to ischemic stroke in children.

Ischemic stroke in children is relatively rare, but it remains an important medical problem. Previous studies on Polish children have implicated dyslipidemias as significant risk factors in stroke. To search for genetic factors associated with the disease, the possible association between apolipoprotein E gene epsilon polymorphism and childhood stroke was evaluated.

The T allele of the 677C>T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children.

Ischemic stroke is a very rare and multifactorial disease in children. The aim of the study was to analyze the relationship between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and stroke in Polish children and to observe whether there is any significant transmission of MTHFR alleles from heterozygous parents to their affected offspring. We analyzed 64 patients with stroke, 122 parents, and 59 healthy children.

[Linear nevus sebaceous syndrome with hemimegalencephaly diagnosed in child in neonatal period].

The aim of this study was to present the case of the child with linear nevus sebaceous syndrome (LNSS) and hemimegalencephaly, diagnosed in neonatal period. It is one of the five epidermal nevus syndromes. Etiology of this multiorgan disease is still unknown.

[Neurocutaneous melanosis and congenital gigantic pigmented nevi in the light of current knowledge].

The aim of this work is to approach the subject of neurocutaneous melanosis and to point out the necessity and precise neurological diagnosis in each case of gigantic pigmented nevi. It is necessary to remember about early planning of skin changes removal which is the cause of lowering risk of malignant melanoma.