Publications by authors named "Joanna Ewa Sawicka"
Purpose: Amplification of 8p12 is frequent in breast cancer and associated with poor prognosis in luminal subtypes. ZNF703 has been identified as the driver gene of proliferation in the A1 amplicon situated in 8p12. In this study, the aims were to investigate associations between ZNF703 copy number alterations and molecular subtypes, proliferation and prognosis, and using immunohistochemistry, examine associations between ZNF703 copy number and ZNF703 protein expression.
View Article and Find Full Text PDFThe prognostic value of androgen receptors in breast cancer subtypes.
Breast Cancer Res Treat
November 2018
Article Synopsis
- The study investigates the relationship between androgen receptor (AR) expression and various clinicopathological features in 1297 primary breast tumors and 336 paired axillary lymph node metastases from Norwegian patients.
- Results show that 78% of tumors are AR-positive, with the highest positivity in Luminal B tumors, and a significant 21.4% discordance in AR status between primary tumors and metastases, often showing a switch from positive to negative status in lymph nodes.
- AR expression in primary tumors is identified as a favorable prognostic marker, especially in Luminal A and grade 3 tumors, suggesting its importance in predicting breast cancer outcomes.