The Role of IgG4 in Autoimmunity and Rheumatic Diseases.

The distinguishing of the IgG4-related disease (IgG4-RD) from among other rheumatic diseases has brought attention to the IgG4 subclass of immunoglobulins. It is the least numerous subclass among immunoglobulins G. In general, IgG4 is considered to be non-inflammatory and tolerance inducing, due to its unique structure.

Spondyloarthritis patients with and without intestinal symptoms - searching for discriminating biomarkers.

Spondyloarthritis (SpA) is often complicated with subclinical gut inflammation. This study was aimed at searching for biomarkers discriminating SpA patients with and without intestinal symptoms. A group of 29 SpA patients and 33 healthy volunteers (control) were included in the study.

Cytokines and integrins related to inflammation of joint and gut in patients with spondyloarthritis and inflammatory bowel disease.

Objectives: Inflammatory bowel disease (IBD) and spondyloarthritis (SpA) have some overlapping clinical features, i.e. gut and joint inflammation.

Inflammatory bowel disease-related arthritis - clinical evaluation and possible role of cytokines.

Objectives: In inflammatory bowel disease (IBD), characterized by chronic mucosal inflammation, rheumatic abnormalities ranging from arthralgia to spondyloarthritis (SpA) are the most common extraintestinal manifestations. The pathogenesis of IBD-related arthritis is unclear. In this study, we search for clinical and immunological differences between patients with IBD-associated spondyloarthritis and IBD patients without SpA symptoms.

Repeated ventricular.

Few publications report the possibility of "torsade de pointes"" (TdP) type tachycardia and ventricular fibrillation occurring in patients with prolonged QT syndrome in the course of hypothyroidism. The authors present the case of a 51-year-old woman with Hashimoto disease and hypothyroidism, inadequately supplemented with L-thyroxine. This patient was admitted to the ward with symptoms of hypometabolic crisis.