Publications by authors named "Joanna Daigle"
Article Synopsis
- PPARγ is a nuclear transcription factor that regulates metabolism, inflammation, and immune responses and is activated by both natural and synthetic compounds.
- PPARγ is particularly important in alveolar macrophages, which are key cells in fighting off airborne infections like Mycobacterium tuberculosis (M.tb).
- A study using mice lacking PPARγ in macrophages found that this absence decreases M.tb growth, increases inflammation, and alters immune cell behavior, highlighting PPARγ's role in tuberculosis pathogenesis.
Johne's disease (JD) is a chronic enteric infection of cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP). The high economic cost and potential zoonotic threat of JD have driven efforts to develop tools and approaches to effectively manage this disease within livestock herds.
View Article and Find Full Text PDFReversible protein phosphorylation is a central mechanism for both the transfer of intracellular information and the initiation of cellular responses. Within human medicine, considerable emphasis is placed on understanding and controlling the enzymes (kinases) that are responsible for catalyzing these modifications. This is evident in the prominent use of kinase inhibitors as drugs as well as the trend to understand complex biology and identify biomarkers via characterizations of global kinase (kinome) activity.
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