Severe bleeding and miscarriages in a hypofibrinogenemic woman heterozygous for the gamma Ala82Gly mutation.

We report a case of hypofibrinogenemia caused by heterozygosity for gamma Ala82Gly in a 69-year-old Polish woman with severe bleeding tendency and a history of six miscarriages. She suffered from frequent mucocutaneous bleedings, epistaxes requiring therapeutic interventions, prolonged bleedings after tooth extractions and surgical interventions. Her mother and sister had bleeding tendency.

[Granulocytic sarcoma with late transformation into acute myeloblastic leukemia--case report].

Case presentation of a 28-year-old patient with acute myeloblastic leukemia (FAB AML-M4), who underwent surgery of an inguinal tumor a year before the diagnosis of leukemia was made. In retrospective assessment a diagnosis of granulocytic sarcoma was made. After induction and consolidation chemotherapy he achieved complete hematological remission and underwent matched unrelated donor bone marrow transplantation.