Publications by authors named "Joanna Bartus"
Clinical outcomes in patients with acute myocardial infarction treated with primary percutaneous coronary intervention stratified according to duration of pain-to-balloon time and type of myocardial infarction.
Cardiol J
November 2023
Article Synopsis
- The study aimed to evaluate the impact of pain-to-balloon (PTB) time on mortality and major adverse cardiac and cerebrovascular events (MACCE) in patients with STEMI and NSTEMI treated with primary percutaneous coronary intervention (pPCI).
- It analyzed data from 1,994 STEMI and 923 NSTEMI patients in Poland between January 2014 and December 2017, focusing on mortality and MACCE rates at different follow-up intervals.
- The results indicated that while there were no significant differences in mortality or MACCE between STEMI and NSTEMI groups overall, longer PTB times were associated with higher mortality in STEMI patients at the 36-month mark.
A topic already widely investigated is the negative prognostic value regarding the extent of high sensitive troponin I (hs-TnI) increases among patients with myocardial infarction (MI) and obstructive coronary atherosclerosis compared to a group of patients with MI and non-obstructive coronary atherosclerosis (MINOCA). Thus, the aim of this study was to evaluate the prognostic value concerning the extent of hs-TnI increase on clinical outcomes among patients with a MINOCA working diagnosis. We selected 337 consecutive patients admitted to hospital with a working diagnosis of MINOCA.
View Article and Find Full Text PDFIt is suggested that vasoconstriction mediated by angiotensin II cleaved from angiotensin I by angiotensin converting enzyme (ACE) is counterbalanced by concomitant formation of vasodilator angiotensin (1-7) by neutral endopeptidase (NEP). Here, we tested this hypothesis using as a bioassay the isolated rat lung perfused with Krebs-Henseleit (KH) solution and ventilated with negative pressures. Addition of angiotensin I (100 nM) into the isolated lung resulted in an immediate increase in pulmonary arterial pressure (Delta PAP) which was not accompanied by a significant change in respiratory lung function or weight of the lung.
View Article and Find Full Text PDFRecent evidence suggests that hypoxic pulmonary vasoconstriction (HPV) is mediated by hypoxia-induced closure of voltage-gated potassium channels in pulmonary vascular smooth muscle cells. It is also claimed that various vasoconstrictor mediators such as thromboxane A2 (TXA2), platelet activating factor (PAF), cysteinyl leukotrienes (cys-LTs) or endothelin-1 (ET-1) contribute to HPV. Their role, however, has not been unequivocally accepted.
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