Publications by authors named "Joana S L Oliveira"
Article Synopsis
- The stratum corneum is a crucial barrier in the skin, primarily composed of lipids, particularly ceramides (CERs), which protect against damage.
- Research focused on the α-OH phytosphingosine CER class to examine the differences between the naturally occurring d-form and the synthetically produced l-form in terms of their structural and chemical properties.
- The study found that the d-form creates a beneficial hydrogen bonding network, forming a stable supramolecular lattice, while the l-form lacks this ability, affecting how these CERs behave in both 2D and 3D model systems.
Ceramide-1-phosphate (C1P) plays an important role in several biological processes, being identified as a key regulator of many protein functions. For instance, it acts as a mediator of inflammatory responses. The mediation of the inflammation process happens due to the interaction of C1P with the C2 domain of cPLA2α, an effector protein that needs the presence of submicromolar concentrations of calcium ions.
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