Publications by authors named "Joana P Mota"
Article Synopsis
- Lipidic implants are effective for controlled drug delivery with good biocompatibility, but they often have rigid drug release profiles that limit their effectiveness.
- Researchers developed lipidic implants containing caffeine, salicylic acid, and rutin, experimenting with different materials like Gelucire 50/02, sucrose, and biobased ionic liquids (ILs) to enhance drug release.
- The findings indicated that ILs, particularly [Cho][Glu], significantly improved drug incorporation and release profiles, making them promising options for improving lipid-based drug delivery systems.
Article Synopsis
- Bacterial nanocellulose (BNC) membranes show promise for topical drug delivery due to their biocompatibility and nanoporous structure that can hold diverse active pharmaceutical ingredients (APIs).
- A study tested the long-term storage stability of BNC membranes containing various APIs under different temperature and humidity conditions, finding that they generally remained stable with minimal changes in structure or drug release profiles.
- Caffeine-loaded BNC membranes were further evaluated for skin compatibility on volunteers, showing good results, which supports their potential as effective dermal drug delivery systems.
Article Synopsis
- Poor drug solubility is a challenge for topical formulations, but ionic liquids (ILs) may improve drug delivery and efficacy while maintaining cell viability at low concentrations.
- Five ILs were tested for their cytotoxicity and their effects on drug solubility and skin permeation, with choline-based ILs showing the best results for enhancing caffeine solubility and being less toxic compared to imidazole-based ILs.
- The study concluded that choline-based ILs are effective functional ingredients for stable topical formulations, allowing for higher drug loading without compromising safety.
There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release.
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