Publications by authors named "Joana F C Silva"
Article Synopsis
- Different methods for making ranolazine, an anti-anginal drug, more soluble were explored, including mechanochemistry, quench-cooling, and solvent evaporation, leading to new amorphous forms of the drug.
- New polymorphs of ranolazine, identified as II and III, were found to relax into a more stable polymorph I at room temperature, with its crystal structure solved for the first time.
- A co-amorphous mixture of ranolazine and tryptophan showed benefits like a higher glass transition temperature, better stability against crystallization for at least two months, and improved solubility in water.
The concept of co-amorphous systems is introduced in an integrated laboratory experiment, designed for advanced chemistry students, using solvent-free, environmentally friendly mechanochemistry. The dual-drug naproxen-cimetidine co-amorphous system (NPX-CIM) is investigated as an example of the emergent field of medicinal mechanochemistry. Students are trained in solid-state characterization techniques including X-ray powder diffraction, Fourier-transform infrared spectroscopy, and thermal analysis by differential scanning calorimetry.
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