Changes in posed facial expression of emotion across the adult life span.

The purpose of this study was to examine changes in the facial expression of emotion across the adult life span. Two positive and two negative emotional expressions were posed by 30 young (21 to 39 years), 30 middle-aged (40 to 59 years), and 30 older (60 to 81 years) healthy, right-handed women. Photographs of the four emotional expressions were rated by independent judges for intensity, accuracy, and confidence.

Variability and reliability of single serum IGF-I measurements: impact on determining predictability of risk ratios in disease development.

In recent years, a number of investigators have studied the relationship between IGF-I and risk of developing cancer, diabetes or cardiovascular disease. Upper tertile, quartile, and quintile IGF-Is were associated with higher risk of developing cancer, and lowest quartile with cardiac disease and diabetes. As part of a study to correlate serum IGF-Is and growth hormone dynamics in aging, we measured fasting serum IGF-I at baseline and two weeks later in a group of 84 normal volunteers between the ages of 50 and 90 years.