Modic Changes Are Not Associated With Long-term Pain and Disability: A Cohort Study With 13-year Follow-up.

Study Design: A comparative cohort study with 13-year follow-up.

Objective: To assess whether Modic changes (MCs) are associated with long-term physical disability, back pain, and sick leave.

Summary Of Background Data: Previous studies have shown a conflicting association of low back pain (LBP) with MCs and disc degeneration.

Modic changes-Their associations with low back pain and activity limitation: A systematic literature review and meta-analysis.

Background: Previous systematic reviews have reported positive associations between Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new primary studies, there is a need for a comprehensive systematic review. Our objectives were to investigate if MCs are associated with non-specific LBP and/or activity limitation and if such associations are modified by other factors.

Methods: A protocol for this review was registered at PROSPERO prior to commencing the work (PROSPERO record: CRD42015017350).

Back pain was less explained than leg pain: a cross-sectional study using magnetic resonance imaging in low back pain patients with and without radiculopathy.

Background: Cross-sectional studies have shown associations between lumbar degenerative manifestations on magnetic resonance imaging (MRI) and low back pain (LBP). Disc herniations and other degenerative manifestations, however, frequently occur in asymptomatic individuals. The purpose of this cross-sectional study was to analyze for associations between pain intensity and degenerative manifestations and other pain variables in patients for whom prognostic factors have been published previously.

Type 1 Modic changes was a significant risk factor for 1-year outcome in sick-listed low back pain patients: a nested cohort study using magnetic resonance imaging of the lumbar spine.

Background Context: It is not clear whether Modic changes (MC) is associated with low back pain (LBP) outcome.

Purpose: To study associations between baseline degenerative manifestations and outcome in sick-listed LBP patients.

Study Design: Prospective nested cohort study based on a randomized controlled trial.

Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?

Purpose: To investigate the prevalence of infected herniated nucleus material in lumbar disc herniations and to determine if patients with an anaerobic infected disc are more likely to develop Modic change (MC) (bone oedema) in the adjacent vertebrae after the disc herniation. MCs (bone oedema) in vertebrae are observed in 6 % of the general population and in 35-40 % of people with low back pain. These changes are strongly associated with low back pain.

The effect of body position and axial load on spinal canal morphology: an MRI study of central spinal stenosis.

Study Design: A method comparison study.

Objective: To investigate the effect of body position and axial load of the lumbar spine on disc height, lumbar lordosis, and dural sac cross-sectional area (DCSA). SUMMARY OF BACKGROUND DATA.

Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain?

Background: Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a late stage of muscular degeneration, and can be measured in a non-invasive manner using magnetic resonance imaging. The purpose of this study was to investigate if fat infiltration in the lumbar multifidus muscles (LMM) is associated with LBP in adults and adolescents.

Magnetic resonance imaging and low back pain in adults: a diagnostic imaging study of 40-year-old men and women.

Study Design: Cross-sectional cohort study of a general population.

Objective: To investigate "abnormal" lumbar spine magnetic resonance imaging (MRI) findings, and their prevalence and associations with low back pain (LBP).

Summary Of Background Data: The clinical relevance of various "abnormal" findings in the lumbar spine is unclear.

An epidemiologic study of MRI and low back pain in 13-year-old children.

Study Design: Cross-sectional cohort study of a general population.

Objective: To describe associations between "abnormal" lumbar magnetic resonance imaging (MRI) findings and low back pain (LBP) in 13-year old children.

Summary And Background Data: Very little is known about the distribution of lumbar MRI findings and how they are associated with LBP in youngsters.