Publications by authors named "Joan MacGregor"
Purpose: The purpose of this study was to examine measures of chronic disease severity and treatment according to insurance status in a clinical trial setting.
Methods: Baseline insurance status of 776 patients with type 2 diabetes and stable coronary artery disease (CAD) enrolled in the United States in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial was analyzed with regard to measures of metabolic and cardiovascular risk factor control.
Results: Compared with patients with private or public insurance, the uninsured were younger, more often female, and less often white non-Hispanic.
A randomized trial of therapies for type 2 diabetes and coronary artery disease.
N Engl J Med
June 2009
Background: Optimal treatment for patients with both type 2 diabetes mellitus and stable ischemic heart disease has not been established.
Methods: We randomly assigned 2368 patients with both type 2 diabetes and heart disease to undergo either prompt revascularization with intensive medical therapy or intensive medical therapy alone and to undergo either insulin-sensitization or insulin-provision therapy. Primary end points were the rate of death and a composite of death, myocardial infarction, or stroke (major cardiovascular events).
Background: The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial, a National Heart, Lung, and Blood Institute-sponsored study in type 2 diabetic patients with coronary artery disease, completed patient recruitment in March 2005. This trial had a nuclear substudy in addition to many other substudies.
Methods And Results: After patient enrollment, adenosine gated single photon emission computed tomography perfusion imaging is performed at years 1 and 3.