Publications by authors named "Joan M Valls Cuevas"
The emergence of Zika virus (ZIKV) as a global health threat has highlighted the unmet need for ZIKV-specific vaccines and antiviral treatments. ZIKV infects dendritic cells (DC), which have pivotal functions in activating innate and adaptive antiviral responses; however, the mechanisms by which DC function is subverted to establish ZIKV infection are unclear. Here we develop a genomics profiling method that enables discrete analysis of ZIKV-infected versus neighboring, uninfected primary human DCs to increase the sensitivity and specificity with which ZIKV-modulated pathways can be identified.
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- Zika virus (ZIKV) is a mosquito-borne virus that poses significant health risks, particularly causing serious conditions like Congenital Zika Syndrome in newborns and Guillain-Barré syndrome in adults.
- The study tested a treatment called ZIKV-IG, derived from individuals who recovered from ZIKV and had strong antibodies against it, in a mouse model of ZIKV infection.
- Results showed that ZIKV-IG effectively protected mice from severe ZIKV infection, reduced symptoms, and minimized tissue damage, highlighting its potential as a therapeutic option for human ZIKV infections.
The natural mechanisms that direct proteins to membranes are typically complex, requiring multiple steps and accessory components. It would be advantageous to develop simplified methods to direct proteins of interest to phospholipid membranes in a single step. Here we report a modular method for membrane localization of proteins by using chemically modified phospholipid anchors capable of covalent attachment to O(6)-methylguanine DNA methyltransferase (SNAP-tag) fusion proteins.
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