Publications by authors named "Joan I. Smallwood"
Article Synopsis
- Monocytes in blood leukocyte preparations generate a chemotactic factor, neutrophil-activating peptide-2 (NAP-2), that attracts neutrophils.
- The presence of platelets and serine protease inhibitors influences the production of NAP-2 and its effect on neutrophils' chemotactic response.
- Once activated, neutrophils can create a sustained chemotactic gradient, leading to excessive attraction of more neutrophils due to the absence of regulatory factors in EDTA/plasma that typically modulate this response.
In isolated leukocytes, elevation of cAMP can inhibit various proinflammatory and immune functions. The prostaglandins E (PGEs) are known to stimulate leukocyte cAMP production, and for years they have been viewed as potential immunosuppressive and/or anti-inflammatory agents. However, their clinical use is severely limited by extreme metabolic instability and by poor oral absorption, which necessitates administration by infusion or injection.
View Article and Find Full Text PDF