Publications by authors named "Joan Danver"
Article Synopsis
- The Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM) involves expert clinician diagnoses to gather data on ME/CFS from 7 specialty clinics across the US.
- The main goals include using questionnaires to measure illness impacts, assessing the course of the illness, and evaluating differences among patients, alongside a focus on treatments and lab tests used by clinicians.
- Enrollment started in 2012 and will continue until 2017, with an initial group of 471 ME/CFS patients already assessed in the first stage of the study.
Microglia are active players in inflammation, but also have important supporting roles in CNS maintenance and function, including modulation of neuronal activity. We previously observed an increase in the frequency of excitatory postsynaptic current in organotypic brain slices after depletion of microglia using clodronate. Here, we describe that local hippocampal depletion of microglia by clodronate alters performance in tests of spatial memory and sociability.
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