Publications by authors named "Joan Carles Laguna"
Article Synopsis
- LRP1 is important for managing fat and glucose levels in the body, and its upregulation occurs in the heart during dyslipidemia.
- Researchers created a mouse model with LRP1 deficiency specifically in heart cells to study how this impacts metabolism and heart function on a high-fat diet (HFD).
- The study found that mice lacking LRP1 in cardiomyocytes maintained good heart function while resisting negative metabolic effects, linked to enhanced fat oxidation in the liver and increased signaling through ANP, highlighting the importance of LRP1 in regulating energy balance.
Article Synopsis
- Human hepatic lipase (hHL) is a protein found on liver cells that helps break down fats and is linked to obesity.
- In a study with mice, researchers looked at how hHL affects fat metabolism in the liver and fat tissue when the mice ate a fatty diet.
- The results showed that hHL increased fat storage in the liver and fat tissue, making the mice gain more weight, but it didn’t change how well their bodies used sugar.
Apolipoprotein (apo) A-II has been biochemically and genetically linked to familial combined hyperlipidemia. Human ApoA-II transgenic mice and peroxisome proliferator-activated receptor alpha (PPARalpha)-deficient mice share some similar phenotypic characteristics. The aim of this study was to determine whether a fibrate-induced PPARalpha activation corrects the combined hyperlipidemia present in human apoA-II transgenic mice.
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