Publications by authors named "Joan Bacque"
Introduction: The high recombinogenic potential of HIV-1 has resulted in the generation of countless unique recombinant forms (URFs) and around 120 reported circulating recombinant forms (CRFs). Here we identify through analyses of near full-length genomes (NFLG) a new HIV-1 CRF derived from subtypes B and F1.
Methods: HIV-1 protease-reverse transcriptase (Pr-RT) sequences were obtained by RT-PCR amplification from plasma RNA.
Circulating recombinant forms (CRFs) are important components of the HIV-1 pandemic. Among 110 reported in the literature, 17 are BF1 intersubtype recombinant, most of which are of South American origin. Among these, all 5 identified in the Southern Cone and neighboring countries, except Brazil, derive from a common recombinant ancestor related to CRF12_BF, which circulates widely in Argentina, as deduced from coincident breakpoints and clustering in phylogenetic trees.
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- Analysis of HIV-1 sequences from 62 newly diagnosed individuals in Moscow revealed that subtype A is the most common strain, accounting for 62.9% of cases, followed by subtype B (22.6%) and others.
- Subtype A is especially prevalent among people who inject drugs (88.9%) and those with heterosexually acquired infections (77.8%), while subtype B is most common among men who have sex with men (44%).
- The study also noted a newly identified cluster of the Iberian subtype G variant in Russia, indicating an expansion of strain diversity in the region.