Publications by authors named "Joachim Hohmann"

Article Synopsis
  • - The study explores how liver growth behaves after a procedure called ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) by using MRI with a contrast agent (gadoxetic acid) to measure liver volume and function in Wistar rats.
  • - Rats were divided into three groups: ALPPS, major liver resection (LR), and portal vein ligation (PVL), and their liver volume and function were tracked for five days post-surgery.
  • - The results showed that liver function increased more than volume in the ALPPS and LR groups after the first day, with total liver function remaining well above 60% of pre-op values for ALPPS and PVL
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The aim of this study was to demonstrate the correlation between ADC values and the ADC/PSAD ratio for potentially malignant prostate lesions classified into ISUP grades and to determine threshold values to differentiate benign lesions (noPCa), clinically insignificant (nsPCa) and clinically significant prostate cancer (csPCa). We enrolled a total of 403 patients with 468 prostate lesions, of which 46 patients with 50 lesions were excluded for different reasons. Therefore, 357 patients with a total of 418 prostate lesions remained for the final evaluation.

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Objective: To evaluate the sensitivity and specificity of 2-18fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) and ultrasound (US) for staging patients with malignant melanoma.

Methods: In total, 258 patients (112 men and 146 women; mean age, 61 ± 16years) met the primary inclusion criteria for malignant melanoma without further malignancy proven by histopathology. This was a retrospective study of the diagnostic accuracy.

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Background: mpMRI assesses prostate lesions through their PI-RADS score. The primary goal of this prospective study was to demonstrate the correlation of PI-RADS v2 score and the volume of a lesion with the presence and clinical significance of prostate cancer (PCa). The secondary goal was to determine the extent of additionally PCa in inconspicuous areas.

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Article Synopsis
  • After portal vein embolization (PVE), a significant portion of patients (30%) experience failure in achieving successful liver resection, with malnutrition, particularly sarcopenia, identified as a modifiable risk factor that can impact outcomes.
  • A retrospective study across eight centers reviewed 306 patients, revealing that those with sarcopenia had a 21% lower rate of resectability and a 23% reduced kinetic growth rate (KGR) post-PVE.
  • The findings suggest that sarcopenia significantly affects both the likelihood of successful liver resection and the growth rate of the liver after PVE, emphasizing the importance of addressing nutritional status in patient management.
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Renal lesions are frequent random findings on CT, MRI, and conventional ultrasound. Since they are usually found accidentally, the respective examinations have not been performed optimally to provide a conclusive diagnosis, making additional multiphase contrast-enhanced examinations necessary. The aim of the study is to correlate CEUS findings with the final diagnosis and to determine whether it is a suitable method for the conclusive characterization of undetermined renal lesions.

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Background: Ultrasound imaging is utilized in Swiss primary care; however, little is known regarding the extent to which it is performed. With this study, we aim to (1) provide an overview of ultrasound use by general practitioners (GPs), and (2) determine the clinical indications of ultrasound in Swiss general practice.

Methods: This is a quantitative study, analyzing 15 years of billing data from 213 GPs in Central Switzerland, and cross-sectional survey data completed by 61 GPs attending 26 certification and refresher courses offered by the Swiss Society of Ultrasound in Medicine (SGUM).

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Objectives: Initial trauma care could potentially be improved when conventional imaging and selective CT scanning is omitted and replaced by immediate total-body CT (iTBCT) scanning. Because of the potentially increased radiation exposure by this diagnostic approach, proper selection of the severely injured patients is mandatory.

Methods: In the REACT-2 trial, severe trauma patients were randomized to iTBCT or conventional imaging and selective CT based on predefined criteria regarding compromised vital parameters, clinical suspicion of severe injuries, or high-risk trauma mechanisms in five trauma centers.

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Rationale And Objectives: To quantify the power or energy consumption of reporting stations in a radiology department and to consider a hypothetical scenario to reduce energy waste.

Methods: We measured the energy consumption of 36 radiology reporting stations over a mean time frame of about 194 days and then extrapolated results to 1 year. Reporting stations were configured (by default) to enter a stand-by mode after 4 hours of inactivity.

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Background: Immediate total-body CT (iTBCT) is often used for screening of potential severely injured patients. Patients requiring emergency bleeding control interventions benefit from fast and optimal trauma screening. The aim of this study was to assess whether an initial trauma assessment with iTBCT is associated with lower mortality in patients requiring emergency bleeding control interventions.

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Background: Published work suggests a survival benefit for patients with trauma who undergo total-body CT scanning during the initial trauma assessment; however, level 1 evidence is absent. We aimed to assess the effect of total-body CT scanning compared with the standard work-up on in-hospital mortality in patients with trauma.

Methods: We undertook an international, multicentre, randomised controlled trial at four hospitals in the Netherlands and one in Switzerland.

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Objective: The purpose of this article is to investigate the magnitude of dose optimization for a manufacturer-recommended urolithiasis protocol in a second-generation dual-source CT scanner.

Materials And Methods: Custom renal phantoms with 24 stones were scanned using the manufacturer-provided dual-energy CT protocol (tube A, 100 kVp and 210 reference mAs; tube B, 140 kVp and 162 reference mAs) and seven dose-optimized protocols in which the reference tube current-time product setting of tube A was reduced stepwise by 20 mAs. Detection and characterization of the stones was assessed.

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Article Synopsis
  • The European Society of Urogenital Radiology (ESUR) recommends serum creatinine tests for patients at risk of contrast-induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF) during imaging studies like CT and MRI.
  • A study involving 1,389 patients showed that 38% had positive responses concerning their renal health, and specific risk factors, particularly previous renal disease, were linked to lower eGFR values.
  • The authors suggest simplifying the questionnaire and implementing serum creatinine tests for patients over 70 years old but note that tests are not necessary for MRI scans using low-risk contrast agents.
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In the last 10 years the mortality rate of colorectal cancer (CRC) has decreased by more than 20% due to the rising developments in diagnostic techniques and optimization of surgical, neoadjuvant and palliative therapies. Diagnostic methods currently used in the evaluation of CRC are heterogeneous and can vary within the countries and the institutions. This article aims to discuss in depth currently applied imaging modalities such as virtual computed tomography colonoscopy, endorectal ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) in the diagnosis of CRC.

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A 90-year-old woman presented with abdominal pain and vomiting. Initial investigations revealed diffuse abdominal tenderness and fever, combined with leucocytosis and marked elevation of C reactive protein levels. Abdominal CT demonstrated segmental bowel wall thickening in the jejunum near the tip of a ventriculoperitoneal (VP) shunt, which had been placed 17 years before because of hydrocephalus.

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Article Synopsis
  • * The research involved 20 patients with colorectal cancer liver metastases and 21 healthy controls, using MRI to measure arrival times of a contrast agent injected into the bloodstream.
  • * Results indicated that patients with liver metastases had significantly shorter HTTs compared to healthy individuals, confirming that MRI can effectively identify hemodynamic changes in such conditions.
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Objective: The aim of our study was to evaluate the role of standardized video clips compared with still images in the diagnostic accuracy of remote sonographic interpretation.

Methods: We compared the remote interpretation of sonographic examinations acquired with a standardized video clip approach to examinations performed with still images alone in 60 patients with various hepatic and extrahepatic pathologies.

Results: The use of video clips improved the diagnostic accuracy of sonographic studies interpreted remotely compared with the use of still images (p < 0.

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Article Synopsis
  • * A five-point scale was used to categorize the reports, with 79% showing no disagreement, while the majority of disagreements fell into lower risk categories (4 and 3), indicating minor concerns.
  • * Ultimately, there was a low rate of serious misinterpretations (0.8%) from the teleradiology provider, which is better than previously reported rates for in-house staff, suggesting outsourced services can be reliable.
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A-26-year old female patient with chronic Budd-Chiari syndrome due to different underlying blood disorders applied for a two-year followup of the liver with Gadolinium-ethoxybenzyl-diethylenetriaminepentaacetic-acid-(Gd-EOB-DTPA-) enhanced MRI. The liver function tests were raised. Besides showing a progressive hepatosplenomegaly and a cirrhotic liver alteration, the MRI revealed multiple new nodular lesions in all liver segments.

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Background: Computed tomography (CT) scanning has become essential in the early diagnostic phase of trauma care because of its high diagnostic accuracy. The introduction of multi-slice CT scanners and infrastructural improvements made total-body CT scanning technically feasible and its usage is currently becoming common practice in several trauma centers. However, literature provides limited evidence whether immediate total-body CT leads to better clinical outcome then conventional radiographic imaging supplemented with selective CT scanning in trauma patients.

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Article Synopsis
  • - The study aimed to find the best dosage range (0.25 mL, 1.0 mL, 4.0 mL) of BR14 contrast-enhanced ultrasonography (CEUS) for identifying malignant liver lesions in 25 patients with known liver conditions.
  • - Results showed that increasing the dosage led to better detection of lesions, with fewer missed lesions and a reduction in lesion sizes; however, major differences in image quality across doses were not significant.
  • - Safety assessments indicated no serious adverse events, and the optimal BR14 dosage for lesion detection was found to be between 1 mL and 4 mL, producing results similar to contrast-enhanced MRI (CE MRI).
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Objective: To compare on-site and blinded off-site reading of baseline ultrasound (US) and contrast enhanced ultrasound (CEUS) for classification and characterisation of focal liver lesions.

Materials And Methods: 99 patients (57 women and 42 men, age range 18-89 years, mean age: 59 years) with 53 malignant and 46 benign liver lesions were studied with unenhanced US followed by contrast enhanced US after injection of 2.4 ml SonoVue® (Bracco, Milano, Italy).

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