Publications by authors named "Jo Y Son"
Article Synopsis
- - Studies indicate that astrocytes in the medullary dorsal horn (MDH) are crucial in developing pathological pain, yet their structural changes, specifically in peripheral astrocytic processes (PAP), during neuropathic states are not well understood.
- - Research using a rat model post-chronic constriction injury revealed significant increases in the number, area, density, and coverage of ezrin-positive PAPs around presynaptic axon terminals and postsynaptic dendrites compared to control rats.
- - The administration of the mGluR5 antagonist MPEP reversed these structural changes, suggesting that mGluR5 may mediate the reorganization of PAPs and enhance astrocyte-neuron interactions in neuropath
Although numerous studies have described botulinum toxin type A (BTX-A) efficacy against trigeminal neuralgia (TN), the underlying cellular mechanisms remain unclear. We have investigated cellular mechanisms that mediate the antinociceptive effect of BTX-A in a rodent model of TN produced by compression of the trigeminal nerve root (TNR). Anesthetized male Sprague-Dawley rats were fixed in a stereotaxic instrument and compression of the TNR was then achieved with a 4% agar solution.
View Article and Find Full Text PDFReceptor-interacting serine/threonine-protein kinase 1 (RIPK1) participates in the regulation of cellular stress and inflammatory responses, but its function in neuropathic pain remains poorly understood. This study evaluated the role of RIPK1 in neuropathic pain following inferior alveolar nerve injury. We developed a model using malpositioned dental implants in male Sprague Dawley rats.
View Article and Find Full Text PDFBackground: The traditional analgesics used to treat neuropathic pain such as anticonvulsants, opioids, and nonsteroidal anti-inflammatory drugs (NSAIDs) lack efficacy and/or carry unpleasant side effects. The present study aimed to investigate the synergistic antinociceptive effects of co-administered low doses of ibuprofen and dexamethasone in rats with trigeminal neuropathic pain.
Materials And Methods: A Sprague-Dawley rat model for trigeminal neuropathic pain was produced using mal-positioned dental implants.
The study reported here investigated the role of the central vascular endothelial growth factor-A (VEGF-A) pathway in the development of trigeminal neuropathic pain following nerve injury. A Sprague-Dawley rat model of trigeminal neuropathic pain was produced using malpositioned dental implants. The left mandibular second molar was extracted under anesthesia and replaced with a miniature dental implant to induce injury to the inferior alveolar nerve.
View Article and Find Full Text PDFPurpose: Allergic diseases are triggered by Th2-mediated immune reactions to allergens and orchestrated by various immunological factors, including immune cells and cytokines. Although many reports have suggested that childhood is the critical period in the onset of allergic diseases and aging leads to alter the susceptibility of an individual to allergic diseases, age-related changes in various immunological factors in healthy individuals as well as their difference between healthy and allergic children have not yet been established.
Methods: We investigated the ratio of Th1/Th2 cells and the levels of 22 allergy-related cytokines across all age groups in individuals who were classified as clinically non-atopic and healthy.