Publications by authors named "Jo Wheeler"
Article Synopsis
- Noninfectious cutaneous granulomatous disorders like cutaneous sarcoidosis, granuloma annulare, necrobiosis lipoidica, and necrobiotic xanthogranuloma exhibit distinct immune responses and histological features due to variations in macrophage inflammation.
- The study used spatial transcriptomics to analyze the immune activation patterns in these disorders, revealing that each condition has unique characteristics, such as polarized type 1 responses in cutaneous sarcoidosis and mixed type 1 and type 2 responses in granuloma annulare.
- Findings suggest that different immune activation patterns are associated with specific histological changes, highlighting the complexity and individuality of these inflammatory skin conditions.
The purpose of this randomized controlled trial was to examine the effects of a motivational interviewing intervention to improve whole-person lifestyle and reduce cardiovascular disease risk profile. A sample of 111 adults with type 2 diabetes and/or hypertension was recruited from a primary care physician practice. The intervention was facilitated by a program specialist trained in motivational interviewing.
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