Publications by authors named "Jo L Dehoorne"
Article Synopsis
- This study investigates the effectiveness of adalimumab, an anti-TNFα agent, for treating childhood noninfectious uveitis (NIU) and aims to establish a therapeutic range for its trough levels.
- The research involved analyzing serum trough levels in 36 children treated with adalimumab, finding that those who fully responded had higher levels (average 11.8 μg/mL) than partial or non-responders (average 9.2 μg/mL).
- The suggested therapeutic range for optimal clinical effects was determined to be between 9.6 to 13 μg/mL, highlighting the importance of therapeutic drug monitoring to enhance treatment outcomes for these pediatric patients.
A 12-year-old Congolese girl presented with acute renal failure, edema, hypertension, hemoptysis, hematuria, and proteinuria after a history of throat infection. Renal ultrasound showed kidneys of normal size, with increased echogenicity of the cortical parenchyma and decreased corticomedullary differentiation. Other additional investigations showed pancytopenia with decreased complement (low C3 and C4).
View Article and Find Full Text PDFRe: Prevalence and associated factors of enuresis in Turkish children.
Int Braz J Urol
February 2008
Purpose: Desmopressin has been used extensively for primary nocturnal enuresis and it is associated with a low incidence of adverse effects. The only reported serious side effect is seizure or altered levels of consciousness resulting from water intoxication, which has been reported for the nasal spray. We describe 18 children with clinical symptoms of water intoxication due to the prolonged bioactivity of desmopressin nasal spray.
View Article and Find Full Text PDFPurpose: We investigated the role of increased solute excretion in children with desmopressin resistant nocturnal enuresis and nocturnal polyuria.
Materials And Methods: A total of 42 children with monosymptomatic nocturnal enuresis and significant nocturnal polyuria with high nocturnal urinary osmolality (more than 850 mmol/l) were not responding to desmopressin. A 24-hour urinary concentration profile was obtained with measurement of urine volume, osmolality, osmotic excretion and creatinine.