High-performance liquid chromatography (HPLC) as a means of assessing the presence of uric acid in archeological human remains: Challenges and future directions.

Objectives: This research aimed to replicate the Swinson, D., Snaith, J., Buckberry, J.

Kinship practices in Early Iron Age southeast Europe: genetic and isotopic analysis of burials from the Dolge njive barrow cemetery, Dolenjska, Slovenia.

DNA analysis demonstrates that all seven individuals buried in an Early Iron Age barrow at Dolge njive, southeast Slovenia, are close biological relatives. Although group composition does not suggest strict adherence to a patrilineal or matrilineal kinship system, the funerary tradition appears highly gendered, with family links through both the male and female line being important in structuring communities. We explore the implications for our understandings of kinship and funerary practices in Early Iron Age southeast Europe.

An isotope signature for diffuse idiopathic skeletal hyperostosis?

Objectives: Diffuse idiopathic skeletal hyperostosis (DISH) has recurrently been associated with a rich diet (high in protein and higher trophic level foods); however, very few studies have investigated this link using carbon and nitrogen (δC and δN) stable isotope analysis. This paper explores the relationship between DISH and diet in two Roman urban communities by analyzing individuals with and without DISH.

Materials And Methods: δC and δN analysis carried out on collagen from 33 rib samples (No DISH: 27; early DISH: 4; DISH: 2) selected from individuals buried at the Romano-British site of Baldock (UK), 41 rib samples (No DISH: 38; early DISH: 3) from individuals from the Catalan Roman site of Santa Caterina (Barcelona, Spain).

Changes in health with the rise of industry.

Since the publication of the Christ Church Spitalfields crypt, London, in 1993, archaeologists and paleopathologists have increasingly recognized the importance of post-medieval burial assemblages. Increasingly paleopathologists have explored the impact industrialization and urbanization had on disease. This virtual special issue focuses upon a global examination of the transition to industry commencing in the mid-18th century.

The dark satanic mills: Evaluating patterns of health in England during the industrial revolution.

Objective: this research seeks to investigate the impact the industrial revolution had on the population of England.

Materials: Pre-existing skeletal data from 1154 pre-Industrial (1066-1700 CE) and 4157 industrial (1700-1905) skeletons from 21 cemeteries (N = 5411).

Methods: Context number, sex, age-at-death, stature and presence/absence of selected pathological conditions were collated.

The Bioarchaeology of Disability: A population-scale approach to investigating disability, physical impairment, and care in archaeological communities.

Objective: This research introduces 'The Bioarchaeology of Disability' (BoD), a population-scale approach which allows for a comprehensive understanding of physical impairment and disability in past communities through a combination of palaeopathological, funerary, and documentary analyses.

Methods: The BoD consists of three phases: 1) Contextualisation includes period-specific literature review; 2) Data collection consists of palaeopathological re-analysis of all individuals with physical impairment and collation of mortuary treatment data; and 3) Analysis integrates the gathered data, literature review, and theoretical frameworks to explore contemporary perceptions of disability.

Materials: The BoD is demonstrated through an investigation of physical impairment and disability in later Anglo-Saxon England (c.

The impact of industrialization on malignant neoplastic disease of bone in England: A study of medieval and industrial samples.

Objective: The increasing prevalence of malignant disease has been associated with shifts in environmental, socioeconomic, and lifestyle risk factors as well as increased adult lifespan. We examine the relationship between malignant neoplasms affecting bone, age and industrialization.

Materials: Pre-existing skeletal data from 11 medieval (1066-1547, n = 8973) and 14 industrial (1700-1890, n = 4748) cemeteries (N = 13,721) from England.

The prevalence of diffuse idiopathic skeletal hyperostosis in England and Catalonia from the Roman to the post-medieval periods.

Objective: Evaluate the prevalence of DISH through time from the Roman to the post-Medieval period in England and Catalonia.

Material: 281 individuals from England and 247 from Catalonia were analyzed.

Methods: Adult individuals with at least three well-preserved lower thoracic vertebral bodies were analyzed.

Back to the beginning: Identifying lesions of diffuse idiopathic skeletal hyperostosis prior to vertebral ankylosis.

Objective: To better understand the pathogenesis of DISH, identifying early or pre-DISH lesions in the spine and investigating the relationship between spinal and extra-spinal manifestations of DISH.

Material: 44 skeletonized individuals with DISH from the WM Bass Donated Skeletal Collection.

Methods: For each vertebra, location, extension, point of origin and appearance of vertebral outgrowths were recorded.

Radiographically recognizable? An investigation into the appearance of osteomalacic pseudofractures.

Pseudofractures, lucent bands that occur due to a build-up of osteoid, are a key feature of osteomalacia. In paleopathology, pseudofractures are often marked by small, linear cracks in the cortex of the bone surrounded by irregular, bony spicule formation. Radiography can be used to help diagnose pseudofractures, both clinically and in paleopathology.

Comparing apples and oranges: Why infant bone collagen may not reflect dietary intake in the same way as dentine collagen.

Objectives: Recent developments in incremental dentine analysis allowing increased temporal resolution for tissues formed during the first 1,000 days of life have cast doubt on the veracity of weaning studies using bone collagen carbon (δ C) and nitrogen (δ N) isotope ratio data from infants. Here, we compare published bone data from the well-preserved Anglo-Saxon site of Raunds Furnells, England, with co-forming dentine from the same individuals, and investigate the relationship of these with juvenile stature. The high-resolution isotope data recorded in dentine allow us to investigate the relationship of diet with juvenile stature during this critical period of life.

Evaluating osteological ageing from digital data.

Age at death estimation of human skeletal remains is one of the key issues in constructing a biological profile both in forensic and archaeological contexts. The traditional adult osteological methods evaluate macroscopically the morphological changes that occur with increasing age of specific skeletal indicators, such as the cranial sutures, the pubic bone, the auricular surface of the ilium and the sternal end of the ribs. Technologies such as computed tomography and laser scanning are becoming more widely used in anthropology, and several new methods have been developed.

The use of corsetry to treat Pott's disease of the spine from 19th century Wolverhampton, England.

Corsets have been used both to create a fashionable silhouette and as an orthopaedic treatment for spinal conditions, but skeletal changes associated with the use of corsetry are rarely reported on in the palaeopathological literature. Here, we report on a 19th-century adult male with Pott's disease of the vertebral column and related vertebral compression deformities. Wolverhampton HB40 presented destruction of the vertebral bodies of T6 to L4, ankylosis of the apophyseal joints of L1 and L2 and an angular kyphosis of the lumbar region, the result of tuberculosis.

The (mis)use of adult age estimates in osteology.

Context: Adult age-at-death is presented in a number of different ways by anthropologists. Ordinal categories predominate in osteoarchaeology, but do not reflect individual variation in ageing, with too many adults being classified as "middle adults". In addition, mean ages (derived from reference samples) are overly-relied upon when developing and testing methods.

Infant mortality and isotopic complexity: New approaches to stress, maternal health, and weaning.

Objectives: Studies of the carbon and nitrogen stable isotope ratios (δ(13) C and δ(15) N) of modern tissues with a fast turnover, such as hair and fingernails, have established the relationship between these values in mothers and their infants during breastfeeding and weaning. Using collagen from high-resolution dentine sections of teeth, which form in the perinatal period we investigate the relationship between diet and physiology in this pivotal stage of life.

Materials And Methods: Childhood dentine collagen δ(13) C and δ(15) N profiles were produced from horizontal sections of permanent and deciduous teeth following the direction of development.

Picking up the pieces: Utilizing the diagnostic potential of poorly preserved remains.

With pressures on time and resources available to those undertaking research in paleopathology, poorly preserved archaeological human remains can often receive limited attention or be completely excluded from the analysis of archaeological sites. Although incomplete skeletons often yield minimal demographic information and can complicate the diagnosis of some pathological conditions, this is not universal. Significant information can be obtained even in partial remains on metabolic bone diseases (where, by definition, the whole skeleton is involved), and for conditions such as osteoarthritis and fractures which can be diagnosed in isolation.

Surface curvature of pelvic joints from three laser scanners: separating anatomy from measurement error.

Recent studies have reported that quantifying symphyseal and auricular surface curvature changes on 3D models acquired by laser scanners has a potential for age estimation. However, no tests have been carried out to evaluate the repeatability of the results between different laser scanners. 3D models of the two pelvic joints were generated using three laser scanners (Custom, Faro, and Minolta).

Quantitative analysis of the morphological changes of the pubic symphyseal face and the auricular surface and implications for age at death estimation.

Age estimation methods are often based on the age-related morphological changes of the auricular surface and the pubic bone. In this study, a mathematical approach to quantify these changes has been tested analyzing the curvature variation on 3D models from CT and laser scans. The sample consisted of the 24 Suchey-Brooks (SB) pubic bone casts, 19 auricular surfaces from the Buckberry and Chamberlain (BC) "recording kit" and 98 pelvic bones from the Terry Collection (Smithsonian Institution).

Forensic age estimation based on the trabecular bone changes of the pelvic bone using post-mortem CT.

We analyzed the trabecular bone changes in the pubic bone (PB) and in the auricular surface (AS) of the ilium using 319 CT scans of cadavers to estimate the age. Although the sharpness of the trabecular structure decreases in CT images when soft tissues are present, we identified four phases for the changes in PB and five in AS; a juvenile trait in PB and a senile trait in AS helped narrow the age range. High correlation with age was identified for both sexes in PB (F 0.

Weaning at Anglo-Saxon Raunds: Implications for changing breastfeeding practice in Britain over two millennia.

This study investigated stable-isotope ratio evidence of weaning for the late Anglo-Saxon population of Raunds Furnells, Northamptonshire, UK. δ(15)N and δ(13)C values in rib collagen were obtained for individuals of different ages to assess the weaning age of infants within the population. A peak in δ(15) N values at about 2-year-old, followed by a decline in δ(15) N values until age three, indicates a change in diet at that age.

Technical note: Reliability of Suchey-Brooks and Buckberry-Chamberlain methods on 3D visualizations from CT and laser scans.

Previous studies have reported that the ageing method of Suchey-Brooks (pubic bone) and some of the features applied by Lovejoy et al. and Buckberry-Chamberlain (auricular surface) can be confidently performed on 3D visualizations from CT-scans. In this study, seven observers applied the Suchey-Brooks and the Buckberry-Chamberlain methods on 3D visualizations based on CT-scans and, for the first time, on 3D visualizations from laser scans.

Basics in paleodemography: a comparison of age indicators applied to the early medieval skeletal sample of Lauchheim.

Recent advances in the methods of skeletal age estimation have rekindled interest in their applicability to paleodemography. The current study contributes to the discussion by applying several long established as well as recently developed or refined aging methods to a subsample of 121 adult skeletons from the early medieval cemetery of Lauchheim. The skeletal remains were analyzed by 13 independent observers using a variety of aging techniques (complex method and other multimethod approaches, Transition Analysis, cranial suture closure, auricular surface method, osteon density method, tooth root translucency measurement, and tooth cementum annulation counting).