Relationship between physical activity level, telomere length, and telomerase activity.

Purpose: The purpose of this study was to examine the relationship of exercise energy expenditure (EEE) with both telomere length and telomerase activity in addition to accounting for hTERT C-1327T promoter genotype.

Methods: Sixty-nine (n = 34 males; n = 35 females) participants 50-70 yr were assessed for weekly EEE level using the Yale Physical Activity Survey. Lifetime consistency of EEE was also determined.

Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers.

Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE epsilon4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in epsilon4 carriers, but not in the non-carriers after controlling for age, gender, and education (N=54).

The unique relation of physical activity to executive function in older men and women.

Purpose: To determine whether physical activity participation was specifically and positively associated with executive function in older individuals after accounting for age, education, and IQ.

Methods: Participants were 120 healthy men (N = 38) and women (N = 82) aged 65-92 yr (mean = 78.9, SD = 5.