Publications by authors named "Jo Anson"
Objectives: To report the long-term outcomes from a longitudinal psychosocial study that forms part of the 'Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted Screening in men at higher genetic risk and controls' (IMPACT) study. The IMPACT study is a multi-national study of targeted prostate cancer (PrCa) screening in individuals with a known germline pathogenic variant (GPV) in either the BReast CAncer gene 1 (BRCA1) or the BReast CAncer gene 2 (BRCA2).
Subjects And Methods: Participants enrolled in the IMPACT study were invited to complete a psychosocial questionnaire prior to each annual screening visit for a minimum of 5 years.
Article Synopsis
- Li-Fraumeni syndrome (LFS) is a hereditary condition linked to a higher risk of various cancers, with about 70% of affected individuals carrying a detectable genetic variant, but some still remain cancer-free.
- Researchers analyzed the genomes of 396 LFS patients to uncover additional cancer-related genetic factors and identified alternative cancer-associated mutations in those without a known variant.
- The study highlights the need for more comprehensive genetic testing in LFS patients and suggests that cancer risk cannot be solely attributed to single gene mutations, but rather involves a complex interplay of genetic and epigenetic factors.