Publications by authors named "Jo'an Zhu-En Ow"
Defining a threshold surface density of vitronectin for the stable expansion of human embryonic stem cells.
Tissue Eng Part C Methods
February 2011
Article Synopsis
- Current methods for expanding human embryonic stem cells (hESCs) use animal-derived substrates, which limits their use in medicine; this study aims to find a more suitable solution.
- The researchers successfully maintained hESCs on human vitronectin-coated plates for over 20 passages, with the cells remaining pluripotent and genetically stable.
- The study also identified a critical surface density of vitronectin needed for optimal cell attachment and growth, which could help in developing a completely defined, animal-component-free system for stem cell research.