Control of Laves Precipitation in a FeCrAl-based Alloy Through Severe Thermomechanical Processing.

In recent years, the development of nuclear grade FeCrAl-based alloys with enhanced accident tolerance has been carried out for light water reactor (LWR) fuel cladding to serve as a substitute for zirconium-based alloys. To achieve excellent microstructure stability and mechanical properties, the control of precipitation particles is critical for application of FeCrAl-based alloys. In this paper, the effect of thermomechanical processing on the microstructure and precipitation behavior of hot-rolled FeCrAl alloy plates was examined.

An In Vitro Human Lens Capsular Bag Model Adopting a Graded Culture Regime to Assess Putative Impact of IOLs on PCO Formation.

Purpose: To develop a culture regime for the in vitro human lens capsular bag model that better reflects clinical events following cataract surgery and to use this refined model to evaluate the putative impact of IOLs on PCO formation.

Methods: Capsulorhexis and lens extraction were performed on human donor eyes to generate capsular bags attached to the ciliary body by the zonules. Preparations were secured by pinning the ciliary body to a silicone ring and maintaining in 6 mL serum-free EMEM for 28 days or in a graded culture system (days 1-3, 5% human serum and 10 ng/mL TGFβ2; days 4-7, 2% human serum and 1 ng/mL TGFβ2; days 8-14, 1% human serum and 0.

Ion Irradiation-Induced Microstructural Evolution of Ni⁻Mo⁻Cr Low Alloy Steels.

As leading candidates of sheet steels for advanced nuclear reactors, three types of Ni⁻Mo⁻Cr high-strength low alloy (HSLA) steels named as CNST1, CNST2 and CNSS3 were irradiated by 400 keV Fe⁺ with peak fluence to 1.4 × 10, 3.5 × 10 and 7.

Antibody engineering of a cytotoxic monoclonal antibody 84 against human embryonic stem cells: Investigating the effects of multivalency on cytotoxicity.

Antibody fragments have shown targeted specificity to their antigens, but only modest tissue retention times in vivo and in vitro. Multimerization has been used as a protein engineering tool to increase the number of binding units and thereby enhance the efficacy and retention time of antibody fragments. In this work, we explored the effects of valency using a series of self-assembling polypeptides based on the GCN4 leucine zipper multimerization domain fused to a single-chain variable fragment via an antibody upper hinge sequence.