Publications by authors named "Jiyun Lee"

The late endolysosomal compartment plays a crucial role in cancer cell metabolism by regulating lysosomal activity, essential for cell proliferation, and the degradation of cellular components during the final stages of autophagy. Modulating late endolysosomal function represents a new target for cancer therapy. In this study, we investigated the effects of bafilomycin A1 (BA1), a vacuolar H-ATPase inhibitor, on colon cancer and normal colon fibroblasts (CCD-18Co) cells.

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Alternating- and direct-current (ADC) bipolar electropolymerization (EP) offers an efficient and scalable approach for the lateral synthesis of conjugated macromolecules, enabling the simultaneous polymerization and deposition of large conducting polymer films with intriguing fractal-like ramified topographies onto arbitrary insulating substrates under remote control. In this study, we presented the remote synthesis of poly(3,4-ethylenedioxythiophene) (PEDOT):anion sensing films on a plastic substrate, aimed at their use in flexible nitrogen dioxide (NO) gas sensors. Notably, the PEDOT:ClO films exhibited excellent gas-sensing characteristics, with a sensitivity of 54.

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Previous epidemiologic studies examining thyroid function and chemical exposures have typically focused on a single or a limited number of chemical classes, often neglecting the effects of chemical mixtures. This study addressed this gap by exploring the associations between exposure to hundreds of chemicals and thyroid function using an exposome-wide association study (ExWAS) approach and National Health and Nutrition Examination Survey (NHANES) data. We analyzed data from three NHANES cycles (2007-2008, 2009-2010, and 2011-2012), which include measures of thyroid function (free and total triiodothyronine [T3], free and total thyroxine [T4], thyroid-stimulating hormone [TSH]) and chemical biomarker concentrations from 9,082 participants.

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  • The study emphasizes the importance of accurately diagnosing invasive lobular carcinoma (ILC) in breast cancer treatment, as misclassification can impact patient management.
  • Researchers reviewed 481 breast cancer biopsy cases, finding that 43.8% showed patterns indicating ILC but were initially misclassified, highlighting significant diagnostic discrepancies.
  • The results stress the need for improved interpretation of E-cadherin staining and tumor morphology to enhance the accuracy of breast cancer diagnoses in clinical settings.
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Acetaminophen (APAP) is a well-known analgesic used globally. Generally, APAP has been proven to be safe and effective at therapeutic doses; however, it can cause serious liver damage when administered at high levels. We prepared extract (CFE) using the seaweed and confirmed that the CFE contains a substance called Loliolide with antioxidant activity.

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  • * A total of 15,624 images were analyzed, and a specific subset of 222 image pairs was used to evaluate how well the P-unit images could be transformed to resemble those from the R-unit.
  • * Results showed that the harmonized images had better similarity metrics compared to original P-unit images, with experts identifying a significant portion of them as resembling R-unit images, indicating the effectiveness of CycleGAN for this purpose.
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Introduction: Fatty degeneration of the vertebral bodies and paravertebral muscles is associated with the presence, severity, and prognosis of spinal disease such as intervertebral disc degeneration. Therefore, the fat fraction (FF) of the vertebral bodies and paraspinal muscles has been considered a potential biomarker for assessing the pathophysiology, progression, and treatment response of spinal disease. Magnetic resonance spectroscopy (MRS) is considered the reference standard for fat quantification; however, it has limitations of a long acquisition time and is technically demanding.

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In this study, a wearable and highly stretchable organic thermoelectric (TE) generator with a notable power density is developed. A highly stretchable and solution-processable TE/electrode pattern is realized by stepwise-curing elastomeric and conducting network. Significant advances in the TE or electrical properties are obtained for these stretchable patterns through post-activation treatment, which creates long-range charge transport pathways without degrading pre-established elastomeric networks.

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  • Giant bullous emphysema involves large air-filled spaces (bullae) that compress healthy lung tissue and may be misdiagnosed due to the appearance of certain lung cells.
  • A 48-year-old male smoker presented with breathing issues; X-ray revealed a collapsed lung and CT showed both bullous emphysema and lung cancer, but initial tests incorrectly identified the reactive cells as cancer.
  • The case highlights the importance of careful analysis and interpretation of lung cell characteristics to avoid misdiagnosis in patients with similar conditions.
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Atopic dermatitis (AD) is an inflammatory skin disease that affects approximately 15-20 % of the children and 1-3 % of the adults worldwide. Corticosteroids and calcineurin inhibitors are used in AD therapy; however, they cause various side effects. Current studies focus on novel therapeutic targets such as phosphodiesterases (PDEs) to mitigate AD.

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Stable-state emulsions with no phase separation and dispersed-particle aggregation can be utilized in various fields, such as cosmetics, pharmaceuticals, food, and drug delivery. However, the physicochemical properties and stability of emulsions are significantly affected by factors such as concentration, mixing method, droplet size, and temperature. Surfactants (emulsifiers), which are used to form stable emulsions, adversely affect the human body and environment and influence the properties of emulsions, thereby limiting their development.

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Obesity is a complex health condition characterized by excessive adipose tissue accumulation, leading to significant metabolic disturbances such as insulin resistance and cardiovascular diseases. Fatty acid synthase (FAS), a key enzyme in lipogenesis, has been identified as a potential therapeutic target for obesity due to its role in adipocyte differentiation and lipid accumulation. This study employed a multidisciplinary approach involving in silico and in vitro analyses to investigate the anti-adipogenic properties of maclurin, a natural phenolic compound derived from .

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Atopic dermatitis (AD) is the most common inflammatory pruritic skin disease worldwide, characterized by the infiltration of multiple pathogenic T lymphocytes and histological symptoms such as epidermal and dermal thickening. This study aims to investigate the effect of vinpocetine (Vinp; a phosphodiesterase 1 inhibitor) on a 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD-like model. DNCB (1%) was administered on day 1 in the AD model.

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The field of biomimetic electronics that mimic synaptic functions has expanded significantly to overcome the limitations of the von Neumann bottleneck. However, the scaling down of the technology has led to an increasingly intricate manufacturing process. To address the issue, this work presents a one-shot integrable electropolymerization (OSIEP) method with remote controllability for the deposition of synaptic elements on a chip by exploiting bipolar electrochemistry.

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  • The KINDLE-Korea study focused on treatment patterns and outcomes for patients with stage III non-small cell lung cancer (NSCLC) diagnosed from 2013 to 2017.
  • It included 461 patients, predominantly older men with a high percentage of smokers, and found varied treatment approaches, with many receiving chemoradiation or surgery.
  • The study highlighted differences in survival outcomes and identified a need for better treatment options for patients not eligible for surgery, especially before durvalumab became available.
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: A relationship between glaucoma and epiretinal membrane (ERM) has been suggested previously. We investigated the association between intraocular pressure (IOP) fluctuation and idiopathic ERM in patients with glaucoma or glaucoma suspect. : Among patients with glaucoma or glaucoma suspect, data from 43 patients with ERM and 41 patients without ERM were reviewed and analyzed in this retrospective study.

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  • The study investigated the safety of immune-checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) patients with chronic hepatitis B (CHB) and occult hepatitis B infection (OBI).
  • Out of 1277 NSCLC patients, a very low incidence (0.2%) of HBV reactivation was found, primarily in patients with CHB not receiving antiviral treatment, highlighting the necessity for antiviral prophylaxis in those individuals.
  • Overall, the safety and efficacy of ICIs were similar across all groups, suggesting that patients with CHB and OBI can be treated with ICIs without significant additional risks.
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Background: Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was approved by the FDA as a first-in-class KRAS-G12C inhibitor. However, sotorasib still has a derivative barrier, which is not effective for other KRAS mutation types, except for G12C.

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In response to the restriction of phthalate plasticizers, acetyl tributyl citrate (ATBC) and acetyl triethyl citrate (ATEC) have been used in medical devices and food packaging. In the present study, the effects of ATBC and ATEC on the development, behavior, growth hormone (GH)-related endocrine system, neurotransmitters, and oxidative stress of zebrafish embryo or larvae were investigated. After exposure of zebrafish to ATBC and ATEC (0, 0.

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Mental health is influenced by the gut-brain axis; for example, gut dysbiosis has been observed in patients with major depressive disorder (MDD). Gut microbial changes by fecal microbiota transplantation or probiotics treatment reportedly modulates depressive symptoms. However, it remains unclear how gut dysbiosis contributes to mental dysfunction, and how correction of the gut microbiota alleviates neuropsychiatric disorders.

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  • Programmed death-1 (PD-1) and PD-L1 inhibitors like nivolumab have shown potential for treating metastatic esophageal squamous cell carcinoma (ESCC), but research on their use prior to surgery (neoadjuvant therapy) is limited.
  • In a study, 20 patients with operable ESCC received three rounds of nivolumab before surgery, resulting in a major pathologic response (MPR) rate of 11.8% and an immunologic major pathologic response (iMPR) rate of 17.6% when evaluated using new immune-related criteria.
  • The baseline PD-L1 expression was shown to correlate with better responses; specifically, patients with a combined positive score (
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Platycosides, major components of (PG) extract, have been implicated in a wide range of biological effects. In particular, platycodin D (PD) is a well-known main bioactive compound of Platycosides. Despite the biological significance of PD, optimization of extract condition for PD from PG root has not been well investigated.

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  • Giant bullae in the lungs can easily rupture and lead to tension pneumothorax, complicating general anesthesia and potentially causing hemodynamic instability even when they remain unruptured.
  • A 43-year-old male with an abdominal wound presented with a giant emphysematous bulla, and after intubation, his blood pressure and pulse dropped significantly despite treatment.
  • Emergency surgery involving bullectomy is crucial in these cases, as it can stabilize the patient by normalizing vital signs after addressing the bulla before continuing with other surgical procedures.
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