The late endolysosomal compartment plays a crucial role in cancer cell metabolism by regulating lysosomal activity, essential for cell proliferation, and the degradation of cellular components during the final stages of autophagy. Modulating late endolysosomal function represents a new target for cancer therapy. In this study, we investigated the effects of bafilomycin A1 (BA1), a vacuolar H-ATPase inhibitor, on colon cancer and normal colon fibroblasts (CCD-18Co) cells.
View Article and Find Full Text PDFAlternating- and direct-current (ADC) bipolar electropolymerization (EP) offers an efficient and scalable approach for the lateral synthesis of conjugated macromolecules, enabling the simultaneous polymerization and deposition of large conducting polymer films with intriguing fractal-like ramified topographies onto arbitrary insulating substrates under remote control. In this study, we presented the remote synthesis of poly(3,4-ethylenedioxythiophene) (PEDOT):anion sensing films on a plastic substrate, aimed at their use in flexible nitrogen dioxide (NO) gas sensors. Notably, the PEDOT:ClO films exhibited excellent gas-sensing characteristics, with a sensitivity of 54.
View Article and Find Full Text PDFPrevious epidemiologic studies examining thyroid function and chemical exposures have typically focused on a single or a limited number of chemical classes, often neglecting the effects of chemical mixtures. This study addressed this gap by exploring the associations between exposure to hundreds of chemicals and thyroid function using an exposome-wide association study (ExWAS) approach and National Health and Nutrition Examination Survey (NHANES) data. We analyzed data from three NHANES cycles (2007-2008, 2009-2010, and 2011-2012), which include measures of thyroid function (free and total triiodothyronine [T3], free and total thyroxine [T4], thyroid-stimulating hormone [TSH]) and chemical biomarker concentrations from 9,082 participants.
View Article and Find Full Text PDFJ Microbiol Biotechnol
December 2024
Acetaminophen (APAP) is a well-known analgesic used globally. Generally, APAP has been proven to be safe and effective at therapeutic doses; however, it can cause serious liver damage when administered at high levels. We prepared extract (CFE) using the seaweed and confirmed that the CFE contains a substance called Loliolide with antioxidant activity.
View Article and Find Full Text PDFIntroduction: Fatty degeneration of the vertebral bodies and paravertebral muscles is associated with the presence, severity, and prognosis of spinal disease such as intervertebral disc degeneration. Therefore, the fat fraction (FF) of the vertebral bodies and paraspinal muscles has been considered a potential biomarker for assessing the pathophysiology, progression, and treatment response of spinal disease. Magnetic resonance spectroscopy (MRS) is considered the reference standard for fat quantification; however, it has limitations of a long acquisition time and is technically demanding.
View Article and Find Full Text PDFIn this study, a wearable and highly stretchable organic thermoelectric (TE) generator with a notable power density is developed. A highly stretchable and solution-processable TE/electrode pattern is realized by stepwise-curing elastomeric and conducting network. Significant advances in the TE or electrical properties are obtained for these stretchable patterns through post-activation treatment, which creates long-range charge transport pathways without degrading pre-established elastomeric networks.
View Article and Find Full Text PDFJ Cardiothorac Surg
October 2024
Atopic dermatitis (AD) is an inflammatory skin disease that affects approximately 15-20 % of the children and 1-3 % of the adults worldwide. Corticosteroids and calcineurin inhibitors are used in AD therapy; however, they cause various side effects. Current studies focus on novel therapeutic targets such as phosphodiesterases (PDEs) to mitigate AD.
View Article and Find Full Text PDFStable-state emulsions with no phase separation and dispersed-particle aggregation can be utilized in various fields, such as cosmetics, pharmaceuticals, food, and drug delivery. However, the physicochemical properties and stability of emulsions are significantly affected by factors such as concentration, mixing method, droplet size, and temperature. Surfactants (emulsifiers), which are used to form stable emulsions, adversely affect the human body and environment and influence the properties of emulsions, thereby limiting their development.
View Article and Find Full Text PDFObesity is a complex health condition characterized by excessive adipose tissue accumulation, leading to significant metabolic disturbances such as insulin resistance and cardiovascular diseases. Fatty acid synthase (FAS), a key enzyme in lipogenesis, has been identified as a potential therapeutic target for obesity due to its role in adipocyte differentiation and lipid accumulation. This study employed a multidisciplinary approach involving in silico and in vitro analyses to investigate the anti-adipogenic properties of maclurin, a natural phenolic compound derived from .
View Article and Find Full Text PDFKorean J Physiol Pharmacol
July 2024
Atopic dermatitis (AD) is the most common inflammatory pruritic skin disease worldwide, characterized by the infiltration of multiple pathogenic T lymphocytes and histological symptoms such as epidermal and dermal thickening. This study aims to investigate the effect of vinpocetine (Vinp; a phosphodiesterase 1 inhibitor) on a 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD-like model. DNCB (1%) was administered on day 1 in the AD model.
View Article and Find Full Text PDFThe field of biomimetic electronics that mimic synaptic functions has expanded significantly to overcome the limitations of the von Neumann bottleneck. However, the scaling down of the technology has led to an increasingly intricate manufacturing process. To address the issue, this work presents a one-shot integrable electropolymerization (OSIEP) method with remote controllability for the deposition of synaptic elements on a chip by exploiting bipolar electrochemistry.
View Article and Find Full Text PDF: A relationship between glaucoma and epiretinal membrane (ERM) has been suggested previously. We investigated the association between intraocular pressure (IOP) fluctuation and idiopathic ERM in patients with glaucoma or glaucoma suspect. : Among patients with glaucoma or glaucoma suspect, data from 43 patients with ERM and 41 patients without ERM were reviewed and analyzed in this retrospective study.
View Article and Find Full Text PDFBackground: Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was approved by the FDA as a first-in-class KRAS-G12C inhibitor. However, sotorasib still has a derivative barrier, which is not effective for other KRAS mutation types, except for G12C.
View Article and Find Full Text PDFIn response to the restriction of phthalate plasticizers, acetyl tributyl citrate (ATBC) and acetyl triethyl citrate (ATEC) have been used in medical devices and food packaging. In the present study, the effects of ATBC and ATEC on the development, behavior, growth hormone (GH)-related endocrine system, neurotransmitters, and oxidative stress of zebrafish embryo or larvae were investigated. After exposure of zebrafish to ATBC and ATEC (0, 0.
View Article and Find Full Text PDFMental health is influenced by the gut-brain axis; for example, gut dysbiosis has been observed in patients with major depressive disorder (MDD). Gut microbial changes by fecal microbiota transplantation or probiotics treatment reportedly modulates depressive symptoms. However, it remains unclear how gut dysbiosis contributes to mental dysfunction, and how correction of the gut microbiota alleviates neuropsychiatric disorders.
View Article and Find Full Text PDFPlatycosides, major components of (PG) extract, have been implicated in a wide range of biological effects. In particular, platycodin D (PD) is a well-known main bioactive compound of Platycosides. Despite the biological significance of PD, optimization of extract condition for PD from PG root has not been well investigated.
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