Exploring the impact of three-dimensional patient satisfaction structure on adherence to medication and non-pharmaceutical treatment: a cross-sectional study among patients with hypertension in rural China.

Background: Hypertension is a chronic disease that requires strict adherence to therapeutic recommendations. While some studies have shown an association between hypertensive patient satisfaction and treatment adherence, research on the relationship between multi-dimensional satisfaction and patient adherence to medication as well as non-pharmaceutical treatment remains limited. This study aimed to examine the association among multiple dimensions of patient satisfaction and adherence among patients with hypertension in rural China.

Bayesian-frequentist hybrid inference framework for single cell RNA-seq analyses.

Background: Single cell RNA sequencing technology (scRNA-seq) has been proven useful in understanding cell-specific disease mechanisms. However, identifying genes of interest remains a key challenge. Pseudo-bulk methods that pool scRNA-seq counts in the same biological replicates have been commonly used to identify differentially expressed genes.

Municipal solid waste gasification by hot recycling blast furnace gas coupled with in-situ decarburization to prepare blast furnace injection of hydrogen-rich gas.

Waste-to-energy is one of the most effective methods to save energy and reduce carbon emissions. This paper proposes a novel process of municipal solid waste (MSW) gasification by hot recycling blast furnace gas (BFG) coupled with in-situ decarburization to prepare blast furnace injection of hydrogen-rich gas. MSW gasification by the hot BFG is conducted by using Aspen Plus software coupled with equilibrium model or kinetic model.

Bayesian-frequentist hybrid inference framework for single cell RNA-seq analyses.

Background: Single cell RNA sequencing technology (scRNA-seq) has been proven useful in understanding cell-specific disease mechanisms. However, identifying genes of interest remains a key challenge. Pseudo-bulk methods that pool scRNA-seq counts in the same biological replicates have been commonly used to identify differentially expressed genes.

Disorder-Enriched Magnetic Excitations in a Heisenberg-Kitaev Quantum Magnet Na_{2}Co_{2}TeO_{6}.

Using optical magnetospectroscopy, we investigate the magnetic excitations of Na_{2}Co_{2}TeO_{6} in a broad magnetic field range (0  T≤B≤17.5  T) at low temperature. Our measurements reveal rich spectra of in-plane magnetic excitations with a surprisingly large number of modes, even in the high-field spin-polarized state.

Effects of the fundamental axes of variation in structural diversity on the forest canopy temperature in an urban area.

The spatial distribution and heterogeneity of forest canopy elements reveal the fundamental dimensions of plant structure variations. Forests characterized by greater structural complexity and diversity intercept solar radiation more effectively, directly influencing the thermal environment and energy balance of the canopy. However, the axes of variation in the distribution and heterogeneity of the canopy remain largely unknown, which limits our understanding of how structural diversity responds to canopy temperature variability.

scRAA: the development of a robust and automatic annotation procedure for single-cell RNA sequencing data.

A critical task in single-cell RNA sequencing (scRNA-Seq) data analysis is to identify cell types from heterogeneous tissues. While the majority of classification methods demonstrated high performance in scRNA-Seq annotation problems, a robust and accurate solution is desired to generate reliable outcomes for downstream analyses, for instance, marker genes identification, differentially expressed genes, and pathway analysis. It is hard to establish a universally good metric.

Single-cell landscape analysis unravels molecular programming of the human B cell compartment in chronic GVHD.

Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell-associated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells continually develop under selective pressure from host alloantigens, aberrant B cell receptor (BCR) activation and IgG production can emerge and contribute to cGVHD pathobiology.

Vibrational spectroscopic detection and analysis of isoniazid-nicotinamide-succinic acid ternary cocrystal.

In this paper, binary and ternary cocrystals in the ternary cocrystal system of isoniazid-nicotinamide-succinic acid were prepared by solvent evaporation and grinding methods. All of them were characterized by terahertz time-domain spectroscopy (THz-TDS), confirming that the cocrystals could be obtained by the above two methods. In addition, to investigate the formation of hydrogen bonds and their influence in cocrystal, several possible forms of hydrogen bond in cocrystal were simulated by density functional theory (DFT).

Clustering Deviation Index (CDI): a robust and accurate internal measure for evaluating scRNA-seq data clustering.

Most single-cell RNA sequencing (scRNA-seq) analyses begin with cell clustering; thus, the clustering accuracy considerably impacts the validity of downstream analyses. In contrast with the abundance of clustering methods, the tools to assess the clustering accuracy are limited. We propose a new Clustering Deviation Index (CDI) that measures the deviation of any clustering label set from the observed single-cell data.

Experimental Study on the Mechanical Properties of Diatomite-Modified Coastal Cement Soil.

Diatomite is a non-metallic mineral resource rich in SiO, which can be used to modify coastal cement soil. In order to explore the mechanical modification effect of diatomite on coastal cement soil at the age of 7 days, based on coastal cement soil with cement content of 5% (mass fraction), diatomite of 0%, 5%, 10%, 15% and 20% (mass fraction) was mixed for modification. Through the unconfined compressive strength test, the triaxial unconsolidated undrained test, backscattered electron imaging (BSE), and energy-dispersive spectroscopy (EDS) technology, the influence of diatomite content and confining pressure on the peak strength of modified coastal cement soil was explored.

Pharmaceutical Cocrystals of Ethenzamide: Molecular Structure Analysis Based on Vibrational Spectra and DFT Calculations.

Pharmaceutical cocrystals can offer another advanced strategy for drug preparation and development and can facilitate improvements to the physicochemical properties of active pharmaceutical ingredients (APIs) without altering their chemical structures and corresponding pharmacological activities. Therefore, cocrystals show a great deal of potential in the development and research of drugs. In this work, pharmaceutical cocrystals of ethenzamide (ETZ) with 2,6-dihydroxybenzoic acid (26DHBA), 2,4-dihydroxybenzoic acid (24DHBA) and gallic acid (GA) were synthesized by the solvent evaporation method.

Adsorption Properties and Mechanism of Attapulgite to Graphene Oxide in Aqueous Solution.

In order to remove toxic graphene oxide (GO) from aqueous solution, attapulgite (ATP) was used as adsorbent to recycle it by adsorption. In this paper, the effects of different pH, adsorbent mass, GO concentration, time and temperature on the adsorption of GO by attapulgite were studied, and the adsorption performance and mechanism were further explored by XRD, AFM, XPS, FTIR, TEM and SEM tests. The results show that when T = 303 K, pH = 3, and the GO concentration is 100 mg/L in 50 mL of aqueous solution, the removal rate of GO by 40 mg of attapulgite reaches 92.

Terahertz and Raman Spectroscopic Investigation of Monohydrate Cocrystal of Antitubercular Isoniazid with Protocatechuic Acid.

Pharmaceutical cocrystal provides an alternative modification strategy for the formulation development of drugs owning to their potential ability to improve the physicochemical properties of active pharmaceutical ingredients (APIs) efficiently by changing inter-molecular interactions between raw materials. Isoniazid (INH) is an indispensable main drug for the treatment of tuberculosis, but its tablet formulation is unstable and prone to degradation. In the present study, the monohydrate cocrystal of INH and protocatechuic acid (PA) was prepared by solvent evaporation using PA as cocrystal former to optimize the properties of INH.

Effect of trust in primary care physicians on patient satisfaction: a cross-sectional study among patients with hypertension in rural China.

Background: In rural areas of China, hypertension is on the rise and it is drawing the Chinese government's attention. The health outcomes of hypertension management can be positively impacted by patient satisfaction with primary care physicians (PCPs), and the influence of patient trust on satisfaction cannot be ignored. This study aimed to analyze the effect of trust in PCPs on patient satisfaction among patients with hypertension in rural China, and the influence of patients' socio-demographic characteristics and hypertension-management-related factors.

Vibrational spectral and structural characterization of multicomponent ternary co-crystal formation within acetazolamide, nicotinamide and 2-pyridone.

Ternary co-crystal, as a novel co-crystal design strategy developed on the basis of binary co-crystal, could be used to improve the physicochemical properties of active pharmaceutical ingredients (APIs) efficiently. However, it is difficult to obtain specific ternary co-crystals since such ternary one involves complex assembly of three different molecules. There are few reports on the micro-molecular structure respect of specific ternary co-crystal systems.