Publications by authors named "Jiyu Li"

It was found that the serine protease inhibitors BmSPI38 and BmSPI39 in silkworm can strongly inhibit the activity of porcine pancreatic elastase, which has potential applicational value in the drug research and development of lung diseases, inflammatory diseases, and skin aging caused by the excessive release of elastase. Previous studies have shown that homotypic multimers obtained by tandem expression can significantly enhance the antifungal activity and structural homogeneity of BmSPI38 and BmSPI39, while the effect of the tandem expression of these two inhibitors, with different combinations, on the total activity and expression levels of multimers remains unclear. The aim of this study is to explore whether it is possible to obtain the combination of BmSPI38 and BmSPI39 with strong total expression activity by protein engineering.

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Ultrasonic-assisted enzymatic extraction (UAEE) was utilized to obtain the polysaccharides from the bark of Presl. (). Taking the yield of the crude polysaccharides from (CCCP) as the assessment indicator, response surface methodology (RSM) and a genetic algorithm-back propagation (GA-BP) artificial neural network model were employed to forecast and contrast the optimal parameters for UAEE.

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Seed hardness is an important quality characteristic of pomegranate fruit. The development of seed hardness relies on the deposition of lignin in the inner seed coat, but the underlying molecular mechanisms remain unclear. In this study, we identified a member of ABCG transporters, PgABCG9, which may function in seed hardening by negatively regulating lignin biosynthesis.

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Ischemia and hypoxia caused by vascular injury intensify nerve damage. Skin precursor-derived Schwann cells have demonstrated an accelerated in vivo prevascularization of tissue-engineered nerves. Furthermore, extracellular vesicles from skin precursor-derived Schwann cells (SKP-SC-EVs) show the potential in aiding peripheral nerve regeneration.

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Light alcohol consumption (LAC) may reduce the incidence and improve the prognosis of ischemic stroke. Recently, we found that LAC promotes cerebral angiogenesis and inhibits early inflammation following ischemic stroke. In addition, LAC upregulates lipocalin-type prostaglandin D2 synthase (L-PGDS) in the brain.

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Background: Ischemic stroke is a leading cause of disability and mortality worldwide, with limited effective treatments. Neuroinflammation plays a crucial role in the progression of ischemic brain injury. Glycoprotein nonmetastatic melanoma protein B (GPNMB) has emerged as a potential regulator of inflammation, but its role and underlying mechanisms in ischemic stroke remain largely unknown.

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Article Synopsis
  • - The Army Ant Nest Textile (ANT) is a smart fabric that adapts to environmental changes, helping individuals manage their health and reduce energy consumption for heating and cooling.
  • - Inspired by army ants, this textile can quickly absorb sweat and change its structure to aid in heat dissipation, while also detecting health signals such as temperature and UV radiation.
  • - With its ability to provide alerts and its compatibility with human use, ANT represents a promising advancement in smart textiles for personal health and energy efficiency.
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The capacity to discern and locate positions in three-dimensional space is crucial for human-machine interfaces and robotic perception. However, current soft electronics can only obtain two-dimensional spatial locations through physical contact. In this study, we report a non-contact position targeting concept enabled by transparent and thin soft electronic skin (E-skin) with three-dimensional sensing capabilities.

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Article Synopsis
  • Wearable haptics enhance the connection between humans and virtual reality or robots, but sweat accumulation affects their performance and comfort.
  • Traditional wearable haptic devices often sacrifice breathability and hygiene for better performance, creating challenges for users.
  • The newly developed Fully Integrated Breathable Haptic Textile (FIBHT) overcomes these issues by offering high-level integration, stretchability, and permeability, providing effective and comfortable feedback for a variety of applications.
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Inflammation of the central nervous system (CNS) is a common feature of neurological disorders and infections, playing a crucial role in the development of CNS-related conditions. CNS inflammation is primarily regulated by glial cells, with astrocytes being the most abundant type in the mammalian CNS. Numerous studies have demonstrated that astrocytes, as immunocompetent cells, perform diverse and complex functions in both health and disease.

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We reported that infiltrated Ly6C macrophages express brain-derived neurotrophic factor (BDNF) only at the cerebral cortex infarct in a rat dMCAO model. However, the changein neuron-expressed BDNF, the niche components that induce the Ly6C cells to express BDNF, and the cellular sources of these components, remain unclear. In this study, immunofluorescence double staining was performed to label BDNF and Ly6C on brain sections at 3, 24, and 48 h following distal middle cerebral artery occlusion (dMCAO) of male rats, and to stain BDNF with Ly6C, IL-4R, and IL-10R.

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With the increase in the aging population, senile osteoporosis (SOP) has become a major global public health concern. Here, it is found that Prx1 and Bmi-1 co-localized in trabecular bone, bone marrow cavity, endosteum, and periosteum. Prx1-driven Bmi-1 knockout in bone-marrow mesenchymal stem cells (BMSCs) reduced bone mass and increased bone marrow adiposity by inhibiting osteoblastic bone formation, promoting osteoclastic bone resorption, downregulating the proliferation and osteogenic differentiation of BMSCs, and upregulating the adipogenic differentiation of BMSCs.

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Copper (Cu) is an essential nutrient for plant growth and development. This metal serves as a constituent element or enzyme cofactor that participates in many biochemical pathways and plays a key role in photosynthesis, respiration, ethylene sensing, and antioxidant systems. The physiological significance of Cu uptake and compartmentalization in plants has been underestimated, despite the importance of Cu in cellular metabolic processes.

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  • The study highlights the growing influence of digital health technologies during the COVID-19 pandemic, emphasizing the importance of patents for understanding industry trends and protecting innovations.
  • The main objective was to analyze digital health patent data from 2017 to 2021 to identify key technological hotspots and development trajectories.
  • Results indicated a total of 15,763 patents, with China leading in submissions, Koninklijke Philips as the top organization, and identified hotspots in areas like medical equipment, image analysis, and electrical diagnosis.
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Wearable electronics with great breathability enable a comfortable wearing experience and facilitate continuous biosignal monitoring over extended periods. However, current research on permeable electronics is predominantly at the stage of electrode and substrate development, which is far behind practical applications with comprehensive integration with diverse electronic components (for example, circuitry, electronics, encapsulation). Achieving permeability and multifunctionality in a singular, integrated wearable electronic system remains a formidable challenge.

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Nerve injury often leads to severe dysfunction because of the lack of axon regeneration in adult mammal. Intriguingly a series of extracellular vesicles (EVs) have the obvious ability to accelerate the nerve repair. However, the detailed molecular mechanisms to describe that EVs switch neuron from a transmitter to a regenerative state have not been elucidated.

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Background: With the aging of the population, colorectal surgeons will have to face more elderly colorectal cancer (CRC) patients in the future. We aim to analyze independent risk factors affecting overall survival in elderly (age ≥65 years) patients with stage II-III CRC and construct a nomogram to predict patient survival.

Methods: A total of 3,016 elderly CRC patients with stage II-III were obtained from the SEER database.

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Disrupted gastrointestinal (GI) motility is highly prevalent in patients with inflammatory bowel disease (IBD), but its potential causative role remains unknown. Herein, the role and the mechanism of impaired GI motility in colitis pathogenesis are investigated. Increased colonic mucosal inflammation is found in patients with chronic constipation (CC).

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Seed weight is an important target trait in pomegranate breeding and culture. Expansins act by loosening plant cell walls and cellulosic materials, permitting turgor-driven cell enlargement. However, the role of expansin genes () in pomegranate seed weight remains elusive.

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Recently, due to the crucial roles of multifunctional liquid manipulation surfaces in biomedical transportation, microfluidics, and chemical engineering, the demand for controllable and functional aspects of directed liquid transportation has increased significantly. However, designing an intelligent manipulation surface that is easy to manufacture and fully functional remains an immense challenge. To address this challenge, a smart surface that can regulate the rate of liquid transport within a patterned channel by temperature is reported.

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Cerebral aneurysms and brain tumors are leading life-threatening diseases worldwide. By deliberately occluding the target lesion to reduce the blood supply, embolization has been widely used clinically to treat cerebral aneurysms and brain tumors. Conventional embolization is usually performed by threading a catheter through blood vessels to the target lesion, which is often limited by the poor steerability of the catheter in complex neurovascular networks, especially in submillimeter regions.

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Article Synopsis
  • Epidemiologic studies show that diabetes worsens the impact of dyslipidemia on cardiovascular disease risk, making it crucial to understand lipid profiles for treatment.
  • Data from the NHANES (2011-2016) reveals surprising dyslipidemia patterns: nearly half of diabetic individuals have normal triglycerides and HDL cholesterol, while others show significant variations.
  • Notably, women with diabetes exhibit higher rates of combined elevated triglycerides and low HDL cholesterol compared to non-diabetic women, highlighting the need for targeted treatment strategies for different dyslipidemia phenotypes in diabetic patients.
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We disclose herein a strategy for the rapid synthesis of versatile organoselenium compounds under mild conditions. In this work, magnesium-based selenium nucleophiles are formed in situ from easily available organic halides, magnesium metal, and elemental selenium via mechanical stimulation. This process occurs under liquid-assisted grinding (LAG) conditions, requires no complicated pre-activation procedures, and operates broadly across a diverse range of aryl, heteroaryl, and alkyl substrates.

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The field boundaries in our country are complex. In attempts to control pests via trichogramma-dominated biological control, the long-term practice of manual trichogramma release has resulted in low control efficiency, thereby impeding sustainable agricultural development. Currently, the novel approach involves utilizing Unmanned Aerial Vehicles (UAVs) for trichogramma balls delivery; however, the system is still in its nascent stages, presenting opportunities for enhancement in terms of stability and accuracy.

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