Role of ROS-mediated PERK/ATF4 signaling activation in extracorporeal tube formation injury of human umbilical vein endothelial cells induced by cooking oil fume PM exposure.

Cooking oil fume-derived PM (COF-PM) is a major source of indoor air contamination in China, which has been demonstrated to be a hazard factor of cardiovascular and cerebrovascular diseases. This study aimed to investigate the role of ROS-mediated PERK/ATF4 signaling activation in COF-PM-inhibited extracorporeal tube formation in human umbilical vein endothelial cells (HUVECs). HUVECs were treated with 100 μg/mL COF-PM at different times, with or without 100 nM PERK activity inhibitor GSK2606414 (GSK) or 200 μM antioxidant N-acetylcysteine (NAC) pretreatment.

Maternal atmospheric particulate matter exposure and risk of adverse pregnancy outcomes: A meta-analysis of cohort studies.

Ambient air particulate exposure not only capable of elevating the risks of adverse pregnancy outcomes, but also has profound implications for human health, but the results are discrepant. This meta-analysis aimed to provide higher grade evidence on the impacts of air particulate on specific pregnancy outcomes. A total of 81 eligible cohort studies were included in this meta-analysis, of which the outcomes included preterm birth (PTB), moderate PTB, very PTB, extreme PTB, term low birth weight (TLBW), term birth weight (TBW), stillbirth (SB) and small for gestational age (SGA).

Uterine decidual stromal cell-derived exosomes mediate the indirect effects of 1-nitropyrene on trophoblast biological behaviors.

1-nitropyrene (1-NP) is representative nitropolycyclic aromatic hydrocarbon pollutant widely present in exhaust particles of internal combustion engine, which is known for its carcinogenicity and mutagenicity. Previous studies have demonstrated that 1-NP has reproductive toxicity, but the specific mechanism is unknown. In this study, Human decidual stromal cells (HDSCs) were treated by 1-NP, exosomes were extracted from the conditioned medium of HDSCs, which were then used to treat human chorionic trophoblast cells (HTR8/SVneo) for 24 h.

Outdoor air pollution exposure and the risk of asthma and wheezing in the offspring.

According to the "fetal origin of disease" hypothesis, air pollution exposure in pregnancy may play an important role in stimulating the early programming of asthma and allergies. However, previous studies reported inconsistent findings. The aim of this meta-analysis was to provide higher grade evidence and quantitatively analyze the link between prenatal exposure to outdoor air pollutants and childhood asthma and wheezing.

Contributions of ambient temperature and relative humidity to the risk of tuberculosis admissions: A multicity study in Central China.

Background: As a communicable disease and major public health issue, many studies have quantified the associations between tuberculosis (TB) and meteorological factors with inconsistent results. The purpose of this multicenter study was to characterize the associations between ambient temperature, humidity and the risk of TB hospitalizations and to investigate potential heterogeneity.

Method: Data on daily hospitalizations for TB, meteorological factors and ambient air pollutants for 16 cities in Anhui Province were collected from 2015 to 2020.

Vitamin D protects intrauterine growth restriction induced by cooking oil fume derived fine particulate matters.

Background: Cooking oil fume (COF) is an important source of indoor air pollution which severely affects human health, and sufficient vitamin D (VitD) is necessary for maternal and child health. However, the effects of cooking oil fume-derived PM (COF-PM) on birth outcomes and whether VitD could protect from adverse effects caused by COFs-PM are still unclear.

Methods: Twenty-four pregnant rats were divided into 4 groups and treated with various treatments: normal feeding, COFs-PM intratracheal instillation, VitD intragastric administration, and COFs-PM and VitD co-treatment, respectively.

MiR-582-3p participates in the regulation of biological behaviors of A549 cells by ambient PM exposure.

Ambient fine particulate matter (PM) is one of the main environmental air pollutants that is closely related to the development of lung cancer, but the mechanisms are unclear. In this study, A549 cells were exposed to ambient PM to investigate the alterations of biological behaviors, and the possible role of miR-582-3p in the effects was further explored. The findings showed that PM exposure could significantly enhance the biological behaviors of A549 cells, and promote their epithelial-mesenchymal transition (EMT) transformation, especially at relatively low doses.

Prenatal air pollution exposure increases the risk of macrosomia: evidence from a prospective cohort study in the coastal area of China.

Effects of prenatal ambient air pollution exposure could increase the risk of adverse pregnancy outcomes, which have been well documented by various studies. However, only very few studies investigated the effects on macrosomia. This study investigated the effects of prenatal air pollution exposure on the risk of macrosomia in a coastal city of China.

Association between preconceptional air pollution exposure and medical purposes for selective termination of pregnancy.

Background: Exposure to air pollutants is associated with adverse pregnancy outcomes. But evidence on the effects of preconceptional air pollution exposure on the risk of termination of pregnancy (TOP) caused by pregnancy losses and congenital malformations is lacking.

Methods: The distributed lag nonlinear model (DLNM) was used to evaluate the impact of short-term air pollutants exposure on the risk of TOP.

Maternal air pollution exposure increases the risk of preterm birth: Evidence from the meta-analysis of cohort studies.

Preterm birth (PTB), a major public health impact, has been shown to be associated with prenatal air pollution exposure, but the results are still inconsistent. This meta-analysis was performed to quantitatively evaluate the correlation between maternal air pollutant exposure and PTB, and provide evidence of higher grade to help improving the pregnancy outcomes. Databases including Web of Science and PubMed were searched to retrieve eligible studies published up to October 2020.

Perinatal low-dose bisphenol AF exposure impairs synaptic plasticity and cognitive function of adult offspring in a sex-dependent manner.

Bisphenol AF (BPAF), a kind of the ideal substitutes of Bisphenol A (BPA), has frequently been detected in environmental media and biological samples. Numerous studies have focused on the reproductive toxicity, cardiotoxicity and endocrine disrupting toxicity of BPAF. However, little evidence is available on neurodevelopmental toxicity of BPAF.

Associations between air pollution exposure and birth defects: a time series analysis.

Air pollution is a serious environmental problem in China. Birth defects are particularly vulnerable to outdoor air pollution. Our study was to evaluate the association between short-term exposure to air pollutants and the risk of birth defects.

Ceramide induces the apoptosis of non‑small cell lung cancer cells through the Txnip/Trx1 complex.

Ceramide is a biologically active sphingomyelin that inhibits cell growth and proliferation. In previous studies, it was demonstrated that the use of lipopolysaccharides induces acid sphingomyelinases to produce ceramide, promoting lung cancer cell apoptosis; however, the specific mechanisms of this action remain unclear. Thioredoxin‑interacting protein (Txnip) plays an important role in the signal transmission of redox reactions inside and outside the cell.

Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation.

Background: This study aimed to explore the effects of ceramide (Cer) on NLRP3 inflammasome activation and their underlying mechanisms.

Methods: Lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced NLRP3 inflammasome activation in J774A.1 cells and THP-1 macrophages was used as an in vitro model of inflammation.

Acute associations between air pollution on premature rupture of membranes in Hefei, China.

Numerous studies had focused on the association between air pollution and health outcomes in recent years. However, little evidence is available on associations between air pollutants and premature rupture of membranes (PROM). Therefore, we performed time-series analysis to evaluate the association between PROM and air pollution.

Associations between weekly air pollution exposure and congenital heart disease.

Background: The topic of congenital heart diseases (CHDs) has attracted more and more attentions. Accumulating evidence suggests that exposure to air pollutants during pregnancy is associated with CHDs, yet the results are inconsistent and study about weekly exposure is few. Our study evaluated the association between weekly air pollution and CHDs in Hefei, China.

Short-term effect of ambient temperature change on the risk of tuberculosis admissions: Assessments of two exposure metrics.

Background: Although the effects of seasonal variations and ambient temperature on the incidence of tuberculosis (TB) have been well documented, it is still unknown whether ambient temperature change is an independent risk factor for TB. The aim of this study was to assess the association between ambient temperature change and the risk of TB admissions.

Method: A distributed lag non-linear model (DLNM) combined with Poisson generalized linear regression model was performed to assess the association between ambient temperature change and the risk of TB admissions from 2014 to 2018 in Hefei, China.

The short-term effect of PM/O on daily mortality from 2013 to 2018 in Hefei, China.

This research intends to explore the short-term impacts of PM/O on daily death in Hefei from 2013 to 2018. Data on daily death of Hefei residents, meteorological factors, and air pollutants were collected from Jan 1, 2013, to Dec 31, 2018. The correlation between PM/O and daily death in Hefei during the research period was studied by time series analysis.

Maternal exposure to air pollution and the risk of low birth weight: A meta-analysis of cohort studies.

Previous studies have evaluated the relationship between prenatal air pollution exposure and low birth weight, but the results are inconsistent. The purpose of this meta-analysis is to quantitatively analyze the relationship between maternal air pollutant exposure and low birth weight (LBW). PubMed and Web of Science databases were searched to obtain the studies on the relationship between the prenatal exposure of air pollutants and LBW that published as of June 2020.

Association between short-term exposure to ambient air pollutants and the risk of tuberculosis outpatient visits: A time-series study in Hefei, China.

Background: The current evidence has presented mixed results between air pollutants exposure and the progression of tuberculosis (TB). The purpose of this study was to explore the association between short-term exposure to air pollutants and the risk of TB outpatient visits in Hefei, China.

Methods: Time-series analysis was used to assess the effect of short-term exposure to ambient air pollutants on the risk of TB outpatient visits.

Effects of long-term exposure to air pollution on the incidence of type 2 diabetes mellitus: a meta-analysis of cohort studies.

This meta-analysis aimed to comprehensively assess the effects of long-term air pollution exposure on the risk of type 2 diabetes mellitus (T2DM). Studies were selected from three electronic databases. Random- or fixed-effect model was used to obtain the pooled hazard ratios (HRs) and corresponding 95% confidential intervals (CIs).

Toxicity of cooking oil fume derived particulate matter: Vitamin D protects tubule formation activation in human umbilical vein endothelial cells.

Cooking oil fumes-derived PM (COFs-derived PM) is the main source of indoor pollution. Exposure to COFs-derived PM can cause oxidative stress and affect angiogenesis. Here we investigated the roles of vitamin D (VD) in protecting tubule formation injury induced by COFs-derived PM, and the roles of ROS/NLRP3/VEGF signaling pathway in the effects.

Associations of ambient PM and O with cardiovascular mortality: a time-series study in Hefei, China.

China is among the countries with the worst air quality throughout the world. As PM was not included in the national air quality monitoring network before January 2013 in China, no study has investigated the associations of ambient PM and O with cardiovascular mortality in Hefei, China. In this time-series analysis, Poisson regression in generalized additive model was adopted to assess the associations between the air pollutants and cardiovascular mortality during the 2013-2015 in Hefei, China.

1,25-Vitamin D3 protects against cooking oil fumes-derived PM2.5-induced cell damage through its anti-inflammatory effects in cardiomyocytes.

The functional role of 1,25-vitamin D3 in cooking oil fumes (COFs)-derived PM2.5-induced cell damage is largely unexplored. The present study investigated the protective role of 1,25-vitamin D3 against cell injury by possible involvement of JAK/STAT and NF-κB signaling pathways in cardiomyocytes.