Publications by authors named "Jiyeoun Lee"
Transcription factors are frequent cancer driver genes, exhibiting noted specificity based on the precise cell of origin. We demonstrate that ZIC1 exhibits loss-of-function (LOF) somatic events in group 4 (G4) medulloblastoma through recurrent point mutations, subchromosomal deletions and mono-allelic epigenetic repression (60% of G4 medulloblastoma). In contrast, highly similar SHH medulloblastoma exhibits distinct and diametrically opposed gain-of-function mutations and copy number gains (20% of SHH medulloblastoma).
View Article and Find Full Text PDFThe development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%).
View Article and Find Full Text PDFArticle Synopsis
- Medulloblastoma has four distinct molecular subgroups (WNT, SHH, Group 3, and Group 4), and current treatment protocols primarily use clinical features for patient stratification, which may not be sufficient for accurate prognostication.
- A study analyzed 673 medulloblastoma cases worldwide to identify molecular biomarkers and developed risk stratification models that combine clinical and cytogenetic factors, enhancing prediction accuracy.
- The research found that subgroup-specific cytogenetic biomarkers can effectively identify very low-risk and very high-risk patients, allowing for better treatment decisions and potential therapy intensification based on individual risk profiles.
Objective/hypothesis: Acoustic analysis is a commonly used method for quantitatively measuring vocal fold function. Voice signals are analyzed by selecting a waveform segment and using various algorithms to arrive at parameters such as jitter, shimmer, and signal-to-noise ratio (SNR). Accurate and reliable methods for selecting a representative vowel segment have not been established.
View Article and Find Full Text PDFUnlabelled: Focal cortical dysplasia (FCD) and mixed neuronal and glial tumors share many clinical characteristics; therefore, the presurgical differential diagnosis of these diseases using MRI is difficult in some cases. The aim of this study was to determine whether (11)C-methionine PET, compared with (18)F-FDG PET, was useful for the evaluation of these diseases.
Methods: The clinical and imaging data of 30 pediatric lesional epilepsy patients pathologically diagnosed with FCD, dysembryoplastic neuroepithelial tumor (DNT), or ganglioglioma were reviewed.