Publications by authors named "Jiyeon You"
Article Synopsis
- - SERTAD1 is identified as an adaptor protein that regulates the K63-linked polyubiquitination of NLRP3, playing a key role in inflammasome activation by interfering with the Cullin1 E3 ubiquitin ligase interaction.
- - The interaction between SERTAD1 and NLRP3 increases following inflammasome activation and is essential for proper secretion of inflammatory cytokines IL-1β and IL-18, as well as the cleavage of gasdermin D.
- - Mice lacking SERTAD1 exhibit less severe inflammation in response to certain conditions, and SERTAD1 expression is found to be elevated in patients with autoimmune diseases, highlighting its importance in NLRP3
NOD-like receptor family protein 3 (NLRP3)-mediated inflammasome activation promotes caspase-1-dependent production of interleukin-1β (IL-1β) and requires the adaptor protein ASC. Compared with the priming and activation mechanisms of the inflammasome signaling pathway, post-translational ubiquitination/deubiquitination mechanisms controlling inflammasome activation have not been clearly addressed. We here demonstrate that the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway by deubiquitinating the lysine 63-linked polyubiquitination of ASC.
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