Parkinson's disease (PD) is a complex neurodegenerative disorder marked by the gradual deterioration of dopaminergic neurons, especially in the substantia nigra pars compacta (SNc). Dysregulation of the transcription factor FoxO1 is associated with various neurodegenerative conditions, including Alzheimer's disease and PD, though the specific mechanisms involved are not fully understood. This study explores the effects of α-Synuclein preformed fibrils (PFF) on BV-2 microglial cells, focusing on changes in molecular characteristics and their impact on neuronal degeneration.
View Article and Find Full Text PDFBackground: GBA1 mutations are the most common genetic risk factor for development of Parkinson's disease (PD). The loss of catalytic activity in GBA1, as well as the reduction of the GBA1 protein in certain cellular compartment, may increase disease progression. However, the mechanisms underlying cellular dysfunction caused by GBA1 deficiency are still mostly unknown.
View Article and Find Full Text PDFIn modern society, people are expected to make scientific decisions and rational actions over a range of personal and social problems. There have been a number of studies on students' and adults' decision-making over socio-scientific issues under the name of scientific literacy. In this study, we investigated the social and cultural backgrounds of Korean people's actions and trust over their personal problems (e.
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