Sevoflurane postconditioning attenuates cardiomyocytes hypoxia/reoxygenation injury via PI3K/AKT pathway mediated HIF-1α to regulate the mitochondrial dynamic balance.

Background: Myocardial ischemia-reperfusion injury (I/RI) is a major cause of perioperative cardiac-related adverse events and death. Studies have shown that sevoflurane postconditioning (SpostC), which attenuates I/R injury and exerts cardioprotective effects, regulates mitochondrial dynamic balance via HIF-1α, but the exact mechanism is unknown. This study investigates whether the PI3K/AKT pathway in SpostC regulates mitochondrial dynamic balance by mediating HIF-1α, thereby exerting myocardial protective effects.

Distribution of ecological restoration projects associated with land use and land cover change in China and their ecological impacts.

China is prone to broad land degradation and thus has been implementing ecological restoration projects (ERPs) since the reform and opening up. The extent of ERPs, as well as the varied planting efforts including tree gain projects (TGPs), grass gain projects (GGPs), and shrub gain projects (SGPs), have remained largely unknown. In addition, the mixed success of ERPs on preventing soil erosion and improving biodiversity is not well known.

Towards an open and synergistic framework for mapping global land cover.

Global land-cover datasets are key sources of information for understanding the complex inter-actions between human activities and global change. They are also among the most critical variables for climate change studies. Over time, the spatial resolution of land cover maps has increased from the kilometer scale to 10-m scale.